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ITK anticorps (AA 596-607)

ITK Reactivité: Humain IHC (p) Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN783291
  • Antigène Voir toutes ITK Anticorps
    ITK (IL2-Inducible T-Cell Kinase (ITK))
    Épitope
    • 14
    • 10
    • 9
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 596-607
    Reactivité
    • 52
    • 20
    • 12
    • 6
    • 3
    Humain
    Hôte
    • 63
    • 6
    • 2
    Chèvre
    Clonalité
    • 64
    • 7
    Polyclonal
    Conjugué
    • 32
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ITK est non-conjugé
    Application
    • 44
    • 37
    • 14
    • 14
    • 12
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This antibody reacts to Interleukin 2 Tyrosine Kinase (ITK).
    Purification
    Immunoaffinity Chromatography
    Immunogène
    Synthetic peptide C-KERPEDRPAFSR from positions 596-607 of human ITK (NP_005537.3). Genename: ITK
    Isotype
    IgG
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    Discover our top product ITK Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0,5 mg/mL
    Buffer
    Tris saline buffer, pH 7.3 containing 0.5 % BSA as stabilizer and 0.02 % sodium azide as preservative
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
  • Antigène
    ITK (IL2-Inducible T-Cell Kinase (ITK))
    Autre désignation
    Tyrosine-Protein Kinase ITK/TSK (ITK Produits)
    Synonymes
    anticorps Emt, anticorps Tcsk, anticorps Tsk, anticorps EMT, anticorps LPFS1, anticorps LYK, anticorps PSCTK2, anticorps IL2 inducible T cell kinase, anticorps IL2 inducible T-cell kinase, anticorps IL2-inducible T-cell kinase, anticorps Itk, anticorps ITK
    Sujet
    Interleukin-2 tyrosine kinase (ITK), a BTK/TEC type tyrosine kinase, is critical for efficient signaling downstream of the T cell receptor. Itk is directly phosphorylated and activated by Lck. Subsequently, Itk activates phospholipase C-gamma1, leading to calcium mobilization and extracellular signal-regulated kinase/mitogen-activated protein kinase activation. Itk contains five domains in addition to the catalytic domain: pleckstrin homology, Tec homology which contains a proline-rich region, Src homology 3, and Src homology 2.Synonyms: EMT, Kinase EMT, LYK, T-cell-specific kinase, Tyrosine-protein kinase Lyk
    ID gène
    3702
    NCBI Accession
    NP_005537
    UniProt
    Q08881
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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