NPC1 anticorps (AA 1181-1278)

N° du produit ABIN872416

Détail du produit anti-NPC1 anticorps

Antigène: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Épitope: AA 1181-1278

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPC1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris

Homologie: Human,Rat,Pig,Chicken,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human NPC1/Niemann Pick C1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur NPC1

Antigène: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Autre désignation: NPC1 (NPC1 Produits)

Synonymes: anticorps NPC, anticorps 9130221N23Rik, anticorps Gm243, anticorps Cdig2, anticorps im:7149020, anticorps wu:fb53a12, anticorps wu:fc29a12, anticorps A430089E03Rik, anticorps C85354, anticorps D18Ertd139e, anticorps D18Ertd723e, anticorps lcsd, anticorps nmf164, anticorps spm, anticorps NPC intracellular cholesterol transporter 1, anticorps NPC1 like intracellular cholesterol transporter 1, anticorps Niemann-Pick disease, type C1, anticorps Niemann-Pick C1 protein, anticorps NPC1, anticorps Npc1l1, anticorps Npc1, anticorps npc1, anticorps LOC579887

Sujet:

Synonyms: Niemann Pick C1, Niemann Pick C1 protein precursor, Niemann Pick disease, type C1, Niemann-Pick C1 protein, NPC, NPC1, NPC1_HUMAN.

Background: This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009].

ID gène: 4864