Phospholipase C gamma 1 anticorps (pTyr771) (AbBy Fluor® 647)

N° du produit ABIN880157

L’anticorps Lapin Polyclonal anti-Phospholipase C gamma 1 a été validé pour WB, IF (p) et IF (cc). Il convient pour détecter Phospholipase C gamma 1 dans des échantillons de Souris.

Aperçu rapide pour Phospholipase C gamma 1 anticorps (pTyr771) (AbBy Fluor® 647) (ABIN880157)

Antigène: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Phospholipase C gamma 1 est conjugé à/à la AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Détail du produit anti-Phospholipase C gamma 1 anticorps (AbBy Fluor® 647)

Épitope: pTyr771

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human PLC gamma 1 around the phosphorylation site of Tyr771

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Phospholipase C gamma 1

Antigène: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Autre désignation: PLC gamma 1

Sujet:

Synonyms: PLC 1, PLC 148, PLC gamma 1, PLC II, PLC1, PLC148, PLCG 1, PLCG1, PLCgamma1, PLCII, triphosphoinositide phosphodiesterase, 1 phosphatidyl D myo inositol 4 5 bisphosphate, 1 phosphatidylinositol 4 5 bisphosphate, 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1, inositoltrisphosphohydrolase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, phosphodiesterase gamma 1, phosphoinositidase C, phosphoinositide phospholipase C, Phospholipase C 148, phospholipase C gamma 1 formerly subtype 148, Phospholipase C gamma 1, phospholipase C-148, PLCG1_HUMAN.

Background: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

ID gène: 5335

Pathways: Signalisation RTK, Signalisation WNT, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, VEGFR1 Specific Signals, VEGF Signaling