FLT3 anticorps (pTyr969) (Alexa Fluor 647)
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- Antigène Voir toutes FLT3 Anticorps
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
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Épitope
- pTyr969
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FLT3 est conjugé à/à la Alexa Fluor 647
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic phosphopeptide derived from human FLT3 around the phosphorylation site of Tyr969
- Isotype
- IgG
- Top Product
- Discover our top product FLT3 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
- Autre désignation
- FLT3 (FLT3 Produits)
- Synonymes
- anticorps FLT3, anticorps B230315G04, anticorps CD135, anticorps Flk-2, anticorps Flk2, anticorps Flt-3, anticorps Ly72, anticorps wmfl, anticorps FLK-2, anticorps FLK2, anticorps STK1, anticorps fms related tyrosine kinase 3, anticorps FMS-like tyrosine kinase 3, anticorps fms-related tyrosine kinase 3, anticorps FLT3, anticorps Flt3
- Sujet
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Synonyms: Flt3 / CD135 phospho Y969, p-Flt3 / CD135 phospho Y969, p-Flt3 phospho Y969, p-CD135 phospho Y969, CD135 antigen, Fetal liver kinase 2, FL cytokine receptor, Flk 2, Flk2, Flt 3, Flt3, FMS like tyrosine kinase 3, Fms related tyrosine kinase 3, Growth factor receptor tyrosine kinase type III, Stem cell tyrosine kinase 1, Stk 1, Stk1, Tyrosine protein kinase receptor FLT3, FLT3_HUMAN.
Background: CD135 is a tyrosine kinase receptor expressed on normal cells including CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML BC. CD135, also known as FMS-like tyrosine kinase 3, FLT3, STK1, and Flk2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc. In humans, expression of Flt3 is restricted to subsets of CD34 positive as well as CD34 negative normal bone marrow cells. In these cells, the level of expression of Flt3 is rather low. Most of the CD34 bright Flt3+ cells co-express CD117 at high levels. They may represent early cycling, but not quiescent stem cells. Flt3+ cells in the CD34lo and CD34- populations do not co-express CD117 Molecule and may represent B lymphoid precursors.
- ID gène
- 2322
- Pathways
- Signalisation RTK
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