C3 anticorps

N° du produit ABIN951636

Détail du produit anti-C3 anticorps

Antigène: C3 (Complement Component 3 (C3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C3 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: Recognizes Complement C3d.
Cellular Localization: Membrane or cytoplasmic.

Purification: Purified

Immunogène: Synthetic peptide corresponding to C3d

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur C3

Antigène: C3 (Complement Component 3 (C3))

Autre désignation: Complement C3 (C3 Produits)

Synonymes: anticorps AHUS5, anticorps ARMD9, anticorps ASP, anticorps C3a, anticorps C3b, anticorps CPAMD1, anticorps AI255234, anticorps HSE-MSF, anticorps Plp, anticorps C3, anticorps C3-1, anticorps sb:cb26, anticorps si:dkey-76b14.4, anticorps wu:fi34b03, anticorps wu:fj86e11, anticorps C3d, anticorps asp, anticorps cpamd1, anticorps c3, anticorps complement C3, anticorps complement component 3, anticorps complement component c3a, duplicate 1, anticorps complement component 3 L homeolog, anticorps complement component C3, anticorps complement C3-like, anticorps C3, anticorps c3a.1, anticorps c3.L, anticorps LOC443475, anticorps c3, anticorps c3-1, anticorps LOC100060539

Sujet: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. C3d deposition in the renal transplant PTCs (peritubular capillaries) is indicative of AR (acute rejection) with subsequent high probability of graft loss. Anti-C3d, combined with anti-C4d, can be utilized as a tool for diagnosis of AR and warrant prompt and aggressive anti-rejection treatment. It was shown that anti-C3d labeled the epidermal basement membrane in 97 % (31/32) cases of bullous pemphigoid (BP), with none of the normal controls demonstrating such findings. In the same study 27 % (3/11) cases of pemphigus vulgaris (PV) demonstrated intercellular C3d deposition. Therefore, C3d immunohistochemistry is a helpful adjunct in the diagnosis of BP (and perhaps PV), especially in the cases in which only formalin-fixed, paraffin embedded tissue is available for analysis.Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CPAMD1, Complement component 3

ID gène: 604

NCBI Accession: NP_001124317

UniProt: P01024

Pathways: Système du Complément, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling