MYLK anticorps (Internal Region)
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- Antigène Voir toutes MYLK Anticorps
- MYLK (Myosin Light Chain Kinase (MYLK))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MYLK est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Séquence
- C-KDTKNMEAKK LSKD
- Specificité
- This antibody is expected to recognise all reported isoforms (NP_444253.3, NP_444254.3, NP_444255.3 and NP_444256.3).
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. - Purification
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
- Immunogène
- Peptide with sequence from the internal region of the protein sequence according to NP_444253.3, NP_444254.3, NP_444255.3, NP_444256.3. Genename: MYLK
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- Discover our top product MYLK Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- MYLK (Myosin Light Chain Kinase (MYLK))
- Autre désignation
- MYLK (MYLK Produits)
- Synonymes
- anticorps AAT7, anticorps KRP, anticorps MLCK, anticorps MLCK1, anticorps MLCK108, anticorps MLCK210, anticorps MSTP083, anticorps MYLK1, anticorps smMLCK, anticorps 9530072E15Rik, anticorps A930019C19Rik, anticorps AW489456, anticorps Mlck, anticorps SMMLCK, anticorps mlck, anticorps fj60a06, anticorps mlck1a, anticorps mylk, anticorps wu:fj60a06, anticorps zmlck1, anticorps myosin light chain kinase, anticorps myosin, light polypeptide kinase, anticorps myosin, light chain kinase a, anticorps MYLK, anticorps Mylk, anticorps mylka
- Sujet
- MLCK, a member of the Ser/Thr protein kinase family, is a calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.Synonyms: Kinase-related protein, MLCK, Myosin light chain kinase, Telokin, smooth muscle
- ID gène
- 4638
- NCBI Accession
- NP_444253
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