SLC6A8 anticorps (Internal Region)

N° du produit ABIN954829

Détail du produit anti-SLC6A8 anticorps

Antigène: SLC6A8 (Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Porc

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC6A8 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: ASLANLTCDQ LADRR

Specificité: This antibody is expected to recognize all reported isoforms (NP_005620.1, NP_001136277.1, NP_001136278.1).

Réactivité croisée (Details): Species reactivity (expected):Human, Rat, Dog, Pig, Cow.
Species reactivity (tested):Mouse.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_005620.1, NP_001136277.1, NP_001136278.1. Genename: SLC6A8

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SLC6A8

Antigène: SLC6A8 (Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8))

Autre désignation: SLC6A8 (SLC6A8 Produits)

Synonymes: anticorps SLC6A8, anticorps chot1, anticorps crtr, anticorps creaT, anticorps CHOT1, anticorps CHT1, anticorps CRT, anticorps CT1, anticorps AA589632, anticorps CRTR, anticorps Creat, anticorps CCDS1, anticorps solute carrier family 6 member 8, anticorps sodium- and chloride-dependent creatine transporter 1, anticorps solute carrier family 6 (neurotransmitter transporter), member 8, anticorps solute carrier family 6 (neurotransmitter transporter, creatine), member 8, anticorps SLC6A8, anticorps LOC473853, anticorps slc6a8, anticorps LOC100440816, anticorps Slc6a8

Sujet: Creatine and creatine phosphate are essential for the maintenance of ATP levels in tissues with high and fluctuating energy demands such as skeletal muscle and brain. Creatine kinase catalyzes the reversible transfer of a phosphate from creatine phosphate to ADP regenerating ATP. In mammals, creatine is either synthesized by sequential reactions occurring in the kidney and liver or obtained from the diet. Muscle cells do not synthesize creatine, but take it up via a special sodium-dependent transporter, the creatine transporter (CRT). Inhibition of creatine transport in experimental animals causes muscle weakness. A specific uptake system for creatine has been demonstrated in skeletal muscle, human monocytes, macrophages, and astroglial-rich cultures. CRT exhibits significant homology to the Na(+) and Cl(-) dependent GABA/norepinephrine (GAT-1/norepinephrine transporter) gene family of neurotransmitter transporters. All members of this family are predicted to contain 12-membrane-spanning domains, to contain a large extracellular loop containing sites for N-linked glycosylation between the third and fourth transmembrane domains, and to have the amino and carboxyl termini facing the cytoplasmic side of the membrane. At least two CRT have been cloned and expressed and characterized. CRT1 or CT1 (mouse, human 635 aa, chromosome X28) is expressed in kidney, muscle, brain, and other tissues, while CT2 (human 426-aa, chromosome 16p11.2) is testis specific.Synonyms: CT1, Creatine transporter 1, Sodium- and chloride-dependent creatine transporter 1, Solute carrier family 6 member 8

ID gène: 6535

NCBI Accession: NP_001136277

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response