NOS1 anticorps (Nitric Oxide Synthase 1, Neuronal) (C-Term)

Details for Product anti-NOS1 Antibody No. ABIN966677, Fournisseur: Connectez-vous pour afficher
Antigène
  • IHPS1
  • N-NOS
  • NC-NOS
  • NOS
  • bNOS
  • nNOS
  • 2310005C01Rik
  • NO
  • NOS-I
  • Nos-1
  • nos
  • NOS1
  • ihps1
  • nnos
  • nos1
  • nos1-A
  • nitric oxide synthase 1
  • nitric oxide synthase 1, neuronal
  • nitric oxide synthase 1 (neuronal)
  • nitric oxide synthase 1 L homeolog
  • NOS1
  • Nos1
  • nos1
  • nos1.L
Épitope
C-Term
41
39
15
15
13
8
8
7
7
6
6
6
6
6
5
5
5
5
5
5
4
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
235
173
150
11
10
10
10
8
7
6
5
4
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
Hôte
Lapin
239
38
18
2
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp NOS1 est non-conjugé
19
14
7
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
222
97
95
49
36
34
30
26
19
18
9
7
6
2
1
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène A synthetic peptide corresponding to a sequence at the C-terminal of human NOS1 , identical to the related mouse and rat sequences.< br/>Immunogen was affinity purified.
Isotype IgG
 Réactivité croisée Souris, Rat (Rattus)
Réactivité croisée (Details) No cross reactivity with other proteins.
Attributs du produit Rabbit IgG polyclonal antibody for Nitric oxide synthase, brain (NOS1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Plasmids, Primers & others Plasmids, Primers & others NOS1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Nitric oxide synthase, brain (NOS1 Antibody Extrait)
Sujet Nitric Oxide Synthase 1 (NOS1,neuronal NOS,nNOS1) is a messenger molecule, mediating the effect of endothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. It may be involved in neuronal cell death and damage in neurological illness. nNOS1 localized to the 12q24. 2 region of human chromosome 12. It splice variant, expressed in testis, that encodes an NH2-terminal truncated protein of 1098 amino acids. nNOS cDNA clones were shown to contain different 5' terminal exons spliced to a common exon 2. Genomic cloning and sequence analysis demonstrate that the unique exons are positioned within 300 bp of each other but separated from exon 2 by an intron that is at least 20 kb in length. The neuronal isoform of nitric oxide synthase is highly expressed in mammalian skeletal muscle, it suggested a specific role for NOS1 in the local metabolic inhibition of alpha-adrenergic vasoconstriction in active skeletal muscle. The novel gaseous neuromediator nitric oxide is thought to play an important role in development and plasticity. Despite this, gene-knockout mice lacking neuronal (Type I) nitric oxide synthase exhibit relatively normal brain development and behavior.
Pathways Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Agent conservateur Sodium azide, Thimerosal (Merthiolate)
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock -20 °C
Stockage commentaire At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
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