NOS2 anticorps (Nitric Oxide Synthase 2, Inducible) (C-Term)

Details for Product anti-NOS2 Antibody No. ABIN966678, Fournisseur: Connectez-vous pour afficher
Antigène
  • HEP-NOS
  • INOS
  • NOS
  • NOS2A
  • NOS-II
  • Nos-2
  • Nos2a
  • i-NOS
  • iNOS
  • iNos
  • NOS2a
  • NOS2
  • BmNOS2
  • Nsl
  • nitric oxide synthase 2
  • nitric oxide synthase 2, inducible
  • inducible nitric oxide synthase
  • NOS2
  • Nos2
  • nos2
Épitope
C-Term
37
18
17
15
10
10
9
7
7
7
7
6
6
6
5
5
5
5
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
268
171
114
17
4
2
1
1
Hôte
Lapin
260
66
1
Clonalité
Polyclonal
Conjugué
Cet anticorp NOS2 est non-conjugé
16
15
6
5
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
258
149
132
79
77
51
38
30
20
19
13
11
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène A synthetic peptide corresponding to a sequence at the C-terminal of human NOS2, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
Isotype IgG
 Réactivité croisée Souris, Rat (Rattus)
Réactivité croisée (Details) No cross reactivity with other proteins.
Attributs du produit Rabbit IgG polyclonal antibody for Nitric oxide synthase, inducible (NOS2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Plasmids, Primers & others Plasmids, Primers & others NOS2 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Nitric oxide synthase, inducible (NOS2 Antibody Extrait)
Sujet Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene. Nitric oxide (NO) is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter, it is implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. Three different NOS isoforms have been identified which fall into two distinct types, constitutive and inducible. The inducible NOS (iNOS) isoform is expressed in a variety of cell types and tissues in response to inflammatory agents and cytokines. The human iNOS (NOS2) gene is approximately 37 kb in length and consists of 26 exons and 25 introns. Diefenbach et al. (1999) studied the relationship of IL12 and nitric oxide synthase-2 (NOS2) to innate immunity to the parasite Leishmania in mice. And conclude that NOS2-derived NO is a prerequisite for cytokine signaling and function in innate immunity. From studies in Tanzania and Kenya, Hobbs et al. (2002) identified a novel single-nucleotide polymorphism, -1173C-T (163730. 0001), in the NOS2 promoter that was significantly associated with protection from symptomatic malaria and severe malarial anemia.
Pathways Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Inositol Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Agent conservateur Sodium azide, Thimerosal (Merthiolate)
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock -20 °C
Stockage commentaire At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Produit citée dans: Hobbs, Udhayakumar, Levesque, Booth, Roberts, Tkachuk, Pole, Coon, Kariuki, Nahlen, Mwaikambo, Lal, Granger, Anstey, Weinberg: "A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children." dans: Lancet (London, England), Vol. 360, Issue 9344, pp. 1468-75, 2002 (PubMed).

Diefenbach, Schindler, Röllinghoff, Yokoyama, Bogdan: "Requirement for type 2 NO synthase for IL-12 signaling in innate immunity." dans: Science (New York, N.Y.), Vol. 284, Issue 5416, pp. 951-5, 1999 (PubMed).

Chartrain, Geller, Koty, Sitrin, Nussler, Hoffman, Billiar, Hutchinson, Mudgett: "Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene." dans: The Journal of biological chemistry, Vol. 269, Issue 9, pp. 6765-72, 1994 (PubMed).

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