IKKi/IKKe anticorps (AA 1-257)

N° du produit ABIN969213

Détail du produit anti-IKKi/IKKe anticorps

Antigène: IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))

Épitope: AA 1-257

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IKKi/IKKe est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of IKBKE (aa1-257) expressed in E. coli.

Clone: 6B4B5

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-IKKi/IKKe (ABIN969213)

Boehm, Zhao, Yao, Kim, Firestein, Dunn, Sjostrom, Garraway, Weremowicz, Richardson, Greulich, Stewart, Mulvey, Shen, Ambrogio, Hirozane-Kishikawa, Hill, Vidal, Meyerson, Grenier, Hinkle, Root et al.: "Integrative genomic approaches identify IKBKE as a breast cancer oncogene. ..." dans: Cell, Vol. 129, Issue 6, pp. 1065-79, (2007) (PubMed).

Luttjeboer, Harada, Hughes, Johnson, Lilford, Mol: "Tubal flushing for subfertility." dans: Cochrane database of systematic reviews (Online), Issue 3, pp. CD003718, (2007) (PubMed).

Sweeney, Mo, Firestein: "Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3." dans: Arthritis and rheumatism, Vol. 56, Issue 3, pp. 743-52, (2007) (PubMed).

Détails sur IKKi/IKKe

Antigène: IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))

Autre désignation: IKBKE (IKBKE Produits)

Synonymes: anticorps zgc:100844, anticorps IKBKE, anticorps MGC130907, anticorps IKK-E, anticorps IKK-i, anticorps IKKE, anticorps IKKI, anticorps AW558201, anticorps IKKepsilon, anticorps Ikki, anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon, anticorps inhibitor of nuclear factor kappa B kinase subunit epsilon, anticorps inhibitor of nuclear factor kappa B kinase subunit epsilon L homeolog, anticorps inhibitor of kappaB kinase epsilon, anticorps IKBKE, anticorps ikbke, anticorps ikbke.L, anticorps Ikbke

Sujet:

Description: Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon.The transcription factor NF?B is retained in the cytoplasm in an inactive form by the inhibitory protein I?B. Activation of NF?B requires that I?B be phosphorylated on specific serine residues, which results in targeted degra-dation of I?B. I?B kinase a(IKKa), previously designated CHUK, interacts with I?B-aand specifically phosphorylates I?B-aon the sites that trigger its degradation, serines 32 and 36. The functional IKK complex contains three subunits, IKKa, IKKßand IKK?(also designated NEMO), and each appear to make essential contributions to I?B phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKKaand IKKß. IKK-i is pri-marily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFa, IL-1 and IL-6. Overexpression of IKK-i was shown to result in phosphorylation of I?Baon Ser32 and Ser36, and in NF?B activation, suggesting that IKK-i may act as an I?B kinase in the immune system.

Aliases: IKBKE

ID gène: 9641

HGNC: 9641

Pathways: Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades