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anti-Mouse (Murine) MC3R Anticorps:
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Human Polyclonal MC3R Primary Antibody pour ELISA, WB - ABIN547431
Mühlhäusler, Adam, Marrocco, Findlay, Roberts, McFarlane, Kauter, McMillen et al.: Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late ... dans The Journal of physiology 2005
MC3Rs expressed in Nkx2.1(+ve) neurons are sufficient to coordinate hypothalamic response and expression of compulsive behavioral responses involving meal anticipation and consumption of large meals during situations of prolonged negative energy balance.
Replacing murine Mc3r with and double-mutant (C17A+G241A) human MC3R showed greater weight and fat mass, increased energy intake and feeding efficiency.
MC1-mediated effects were reduced, and MC3 anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours.
Mc3rs are stronger modulators of food anticipatory activity compared to Ghsrs.
The minimum promoter region required for Mc3r expression has been identified, along with two binding sites for AP-1 and ATF4 and in the 5' upstream-flanking region of Mc3r that are essential for Mc3r expression.
3' RACE experiments using hypothalamic RNA indicated the 3' UTR terminates approximately 1286 bases after the translational stop codon, with a previously unknown 787 base splice between consensus splice donor and acceptor sites.
These data reveal novel protective properties of endogenous MC3 on periodontal status in health and disease
Data suggest that Mc3r (not Mc4r) is expressed in 1/3 of dopaminergic neurons in ventral tegmental area (VTA); global deletion of Mc3r in knockout mice increases VTA dopamine by 42% and decreases sucrose intake/preference in female (not male) mice.
The melanocortin-3 receptors are involved in regulating adaptation to food restriction.
impact of central MC3Rs on behavior and metabolism
Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors.
data suggest that the melanocortin-3 receptor is involved in the control of energy balance and the expression of rhythms anticipating nutrient intake.
MC(3) plays a subtle role in the regulation of food intake
Compared with WT, MC4R-/- showed no activation in area postrema but showed normal activation in paraventricular hypothalamus, whereas MC3R-/- showed reduced activation in PVN but not in AP.
Findings identify MC(3)-mediated signaling as a beneficial pathway in experimental arthritis.
Neural Mc3rs are important for adapting metabolism and maintaining rhythms of liver metabolism during periods when feeding is restricted to the light cycle
The pigmentation of atopic dermatitis is related to increased levels of alpha-MSH, MC1R (in the skin) and MC3R (in intestines).
Results demonstrate that peripherally administered melanocortin receptor 3/4 agonists regulate body weight, liver metabolism and glucose homeostasis through independent pathways.
Agonism at MC3-R expressed on peritoneal macrophages leads to inhibition of experimental nonimmune peritonitis in both wild-type and recessive yellow (e/e) Mc1r-deficient mice.
meta-analysis results supported a recessive inheritance model for MC3R gene as a potential cause of childhood obesity; high clinical heterogeneity existed among studies and thus requires more research of larger participation for future integration of data
AgRP acted as a biased agonist in MC3R, decreasing cAMP activity of constitutively active mutant (F347A) MC3R but stimulating ERK1/2 activation in both wild type and F347A MC3Rs.
This article reviews the MC3R polymorphisms and mutations identified in humans, and the in vitro, murine, and human cohort studies examining their putative effects. Certain human MC3R mutations are associated with greater adiposity and hyperleptinemia. [review]
Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists.
Results show regulation of melanocortin receptors MC2R, MC3R and MC4R gene expressions in CD8(+) cytotoxic T-lymphocytes and CD19(+) B lymphocytes in rheumatoid arthritis (RA) treated with tumor necrosis factor-alpha (TNF-alpha) inhibitor adalimumab.
MC3R mutations are associated with Obesity.
findings support the role of MC3R genetic variants in adiposity gain during early childhood.
There is no evidence of any association between MC3R variations and obesity.
melanocortin receptors MC2R, MC3R and MC5R are most abundantly expressed in glandular epithelium of the endometrium
the DPLIY motif and helix 8 was important for MC3R activation and signal transduction. The data led to a better understanding of the structure-function relationship of MC3R.
novel data about the structure-function relationship of MC3R, identifying residues important for receptor function; some studied mutations exhibited biased signaling, preferentially activating one intracellular signaling pathway.
propose three potential human candidate genes for voluntary physical exercise levels (MC3R, CYP24A1, and GRM8).
The cytoplasmic end of transmembrane domain 3 and the intracellular loop 2 were critical for MC3R function.
MC3R polymorphism is marginally associated in the development of pulmonary tuberculosis in Korean population.
MC3R is a 2-exon gene that requires a 5' UTR for translation, localization, and potential interaction with MRAP2
3' RACE experiments using MC3R transcript indicated the 3' UTR terminates approximately 115-160 bases after the translational stop codon.
observed that a missense variant (rs3827103)in MC3R and the haplotype that it forms with an upstream (rs3746619) variant are associated with systolic blood pressure (SBP); individuals who with these variants exhibit downregulation of MC3R expression and a positive correlation between leptin levels and SBP
This study focused on the search for the MC3R polymorphism in the Polish population.
Overall, the total prevalence of rare MC3R variants was 1 % in Belgian obese children and adolescents compared to 1.02 % in lean controls.
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans.
melanocortin receptor 3
, melanocortin-3 receptor
, obesity quantitative trait locus