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anti-Human GJC1 Anticorps:
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Human Polyclonal GJC1 Primary Antibody pour IHC, IHC (p) - ABIN4300027
Hulikova, Black, Hsia, Wilding, Bodmer, Swietach: Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid. dans Proceedings of the National Academy of Sciences of the United States of America 2016
Horse (Equine) Polyclonal GJC1 Primary Antibody pour WB - ABIN2774871
Terrier-Lacombe, Guillou, Maire, Terrier, Vince, de Saint Aubain Somerhausen, Collin, Pedeutour, Coindre: Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data--a study from the French Federation of Cancer Centers Sarcoma Group. dans The American journal of surgical pathology 2002
Show all 2 Pubmed References
human Cx40 (Montrer GJA5 Anticorps)/Cx45 and Cx43 (Montrer GJA1 Anticorps)/Cx45 heterotypic gap junctions were investigated by recombinant expression in GJ deficient cells.
Observations involving both N- and C-domains of CaM to interact with the Cx45 peptide differ from the embraced interaction with Cx50 (Montrer GJA8 Anticorps) from another connexin family
Human deltoid muscle biopsies of 5 Chilean dysferlinopathy patients exhibited the presence of muscular connexins (Cx40.1 (Montrer GJD4 Anticorps), Cx43 (Montrer GJA1 Anticorps) and Cx45).
Connexin45 has much more rapid gating kinetics than connexin43 (Montrer GJA1 Anticorps)
Results found that the expression of Cx26 (Montrer GJB2 Anticorps) and Cx45 had no prognostic value but Cx43 (Montrer GJA1 Anticorps) was upregulated in tumour epithelia and membrane Cx43 (Montrer GJA1 Anticorps) expression was associated with short overall survival time.
Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 (Montrer GJA1 Anticorps) rather than on Cx45.
Our data suggest that GJA7 alterations have no or low genetic relevance in nonsyndromic hearing loss in populatins from Turkey, South Africa, United Kingdom, United States, and China.
DNA hypermethylation of the promoter region of GJC1, encoding connexin45, is an important mechanism in silencing gene expression in colorectal cancer.
Study shows that fusion of a V5/6-His tag (hexa (Montrer HEXA Anticorps) moiety M r = 0.93 kDa) to the CT segment of Cx40 (Montrer GJA5 Anticorps), Cx43 (Montrer GJA1 Anticorps) and Cx45 does not prevent the cells from forming channels.
connexin genes Gjd2 (Montrer GJD2 Anticorps) coding for mCx36, Gjc1 coding for mCx45 and Gja10 (Montrer GJA9 Anticorps) coding for mCx57 in the mouse, a subset of 4 connexin genes, including the unique GJA9 (Cx59 (Montrer GJA9 Anticorps)) and GJA10 (Cx62 (Montrer GJa10 Anticorps)), could be detected at least as transcript isoforms in the human retina.
Punctate labelling of Cx45 was faint in the cerebellar cortex molecular layer of wild-type mice and was increased in intensity in mice with Cx36 (Montrer GJD2 Anticorps) gene ablation. The vast majority of Cx36 (Montrer GJD2 Anticorps)-puncta co-localized with Cx45-puncta, which in turn was associated with the scaffolding protein zonula occludens-1 (Montrer TJP1 Anticorps).
Results indicate that pre- and peri (Montrer POSTN Anticorps)-implantation development does not require connexin43 (Cx43 (Montrer GJA1 Anticorps)) and connexin45 (Cx45).
The ablation of Cx45 reduced neuronal loss by approximately 50% under ischemic insult.
This study demonstrated using Cx45-eGFP transgenic mice that Cx45-eGFP cells are distributed along the rostrocaudal extent of the spinal cord with expression mainly restricted to the grey matter of dorsal laminae I-III
Prostaglandin E stimulates Connexin isoforms via GSK-3beta/beta-catenin (Montrer CTNNB1 Anticorps) via EP2-receptor-dependent cAMP/PKA and PI3K/Akt (Montrer AKT1 Anticorps) in mouse embryonic stem cells.
Suggest critical role for Cx45 in the regulation of endothelial-induced mesenchymal cell differentiation towards a mural cell phenotype.
Cx45 is required for optimal impulse propagation in the atrioventricular node; cardiomyocyte-directed deficiencies of Cx45 in mice lead to embryonic lethality attributable to morphological and functional cardiovascular defects.
Cx45 is physiologically expressed in vascular smooth muscle
Residual Cx45 and its relationship to Cx43 (Montrer GJA1 Anticorps) in murine ventricular myocardium.
The cx45 strongly modulate the firing pattern of individual RGCs, ensuring strongly correlated firing between nearby RGCs and normal patterning of retinogeniculate projections.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.
, gap junction alpha-7 protein
, gap junction gamma-1 protein
, gap junction protein, gamma 1, 45kDa
, gap junction protein, alpha 7, 45kDa (connexin 45)
, gap junction protein, delta 3, 31.9kDa
, gap junction protein, alpha 7, 45kDa
, gap junction membrane channel protein alpha 7
, gap junction gamma-1 protein-like
, gap junction channel protein connexin 45
, Gap junction alpha-7 protein