anti-Mouton p53 anticorps pour Western Blotting

Recommended p53 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Tumor Protein P53 (TP53) Anticorps
  • BCC7
  • LFS1
  • P53
  • TRP53
  • p53
  • Trp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • tp53
  • Xp53
  • TP53
  • tumor protein p53
  • cellular tumor antigen p53
  • transformation related protein 53
  • tumor protein p53 L homeolog
  • transformation related protein 53, pseudogene
  • Wistar clone pR53P1 p53 pseudogene
  • TP53
  • CpipJ_CPIJ002758
  • Tp53
  • tp53
  • Trp53
  • tp53.L
  • Trp53-ps
  • p53-ps
Épitope
N-Term
173
127
89
83
73
71
70
61
58
54
49
48
47
47
41
38
32
30
28
23
22
20
17
16
15
15
15
15
15
15
14
12
11
11
10
10
9
9
9
8
8
7
7
7
7
7
6
6
6
6
6
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Boeuf (Vache), Chien, Cobaye, Cheval, Humain, Porc, Lapin, Rat (Rattus), Mouton
2376
514
426
190
126
94
87
83
35
22
20
19
18
16
15
13
6
4
4
4
3
3
2
2
1
1
Hôte
Lapin
1348
1139
7
3
1
1
1
1
Clonalité
Polyclonal
Conjugué
Cet anticorp p53 est non-conjugé
81
78
65
54
47
46
45
31
31
26
25
25
25
25
25
24
24
24
20
19
18
14
14
14
14
14
12
7
5
5
5
5
5
5
5
5
4
3
2
2
2
Application
Chromatin Immunoprecipitation (ChIP), Immunohistochemistry (IHC), Western Blotting (WB)
1902
770
743
735
626
623
435
345
317
179
72
41
32
31
21
17
16
15
13
9
9
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Options
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N° du produit ABIN2779317
$ 289.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
3.3325126 ABIN2777951 WB Rabbit N-Term Connectez-vous pour afficher Polyclonal 1
3.3325126 ABIN2779979 WB Rabbit C-Term Connectez-vous pour afficher Polyclonal 1
1 ABIN120054 EIA IHC (fro) IHC (p) IP WB Mouse IgG2a AA 20-25 Connectez-vous pour afficher DO-1 3
1 ABIN320175 EIA IHC (fro) IHC (p) IP WB Mouse IgG2a AA 20-25 Connectez-vous pour afficher DO-1 4
1 ABIN202409 WB Rabbit IgG AA 281-330 Connectez-vous pour afficher Polyclonal
1 ABIN574482 IHC (p) WB Rabbit N-Term Connectez-vous pour afficher Polyclonal
1 ABIN467883 WB Rabbit N-Term Connectez-vous pour afficher Polyclonal

General

Antigène Tumor Protein P53 (TP53) Anticorps
Épitope N-Term
(173), (127), (89), (83), (73), (71), (70), (61), (58), (54), (49), (48), (47), (47), (41), (38), (32), (30), (28), (23), (22), (20), (17), (16), (15), (15), (15), (15), (15), (15), (14), (12), (11), (11), (10), (10), (9), (9), (9), (8), (8), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Boeuf (Vache), Chien, Cobaye, Cheval, Humain, Porc, Lapin, Rat (Rattus), Mouton
(2376), (514), (426), (190), (126), (94), (87), (83), (35), (22), (20), (19), (18), (16), (15), (13), (6), (4), (4), (4), (3), (3), (2), (2), (1), (1)
Hôte Lapin
(1348), (1139), (7), (3), (1), (1), (1), (1)
Clonalité
Polyclonal
Conjugué Cet anticorp p53 est non-conjugé
(81), (78), (65), (54), (47), (46), (45), (31), (31), (26), (25), (25), (25), (25), (25), (24), (24), (24), (20), (19), (18), (14), (14), (14), (14), (14), (12), (7), (5), (5), (5), (5), (5), (5), (5), (5), (4), (3), (2), (2), (2)
Application Chromatin Immunoprecipitation (ChIP), Immunohistochemistry (IHC), Western Blotting (WB)
(1902), (770), (743), (735), (626), (623), (435), (345), (317), (179), (72), (41), (32), (31), (21), (17), (16), (15), (13), (9), (9), (4), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 1 référence disponible
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Détail du produit anti-p53 anticorps

Détail du antigène p53 Information d'application Stockage References for anti-p53 antibody (ABIN2779317) Images
Blocking Peptide Blocking peptide for this product available: ABIN985382
Séquence EEPQSDPSVE PPLSQETFSD LWKLLPENNV LSPLPSQAMD DLMLSPDDIE
Homologie Cow: 100%, Dog: 80%, Guinea Pig: 90%, Horse: 90%, Human: 100%, Pig: 100%, Rabbit: 100%, Rat: 90%, Sheep: 100%
Attributs du produit This is a rabbit polyclonal antibody against TP53. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Immunogène The immunogen is a synthetic peptide directed towards the N terminal region of human TP53

Détail du antigène p53

Détail du produit anti-p53 anticorps Information d'application Stockage References for anti-p53 antibody (ABIN2779317) Images Haut de la page
Antigène
Autre désignation TP53 (TP53 Antibody Extrait)
Sujet TP53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Alias Symbols: LFS1, TRP53, p53
Protein Size: 393
Poids moléculaire 44 kDa
ID gène 7157
NCBI Accession NM_000546, NP_000537
UniProt P04637
Pathways Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy

Information d'application

Détail du produit anti-p53 anticorps Détail du antigène p53 Stockage References for anti-p53 antibody (ABIN2779317) Images Haut de la page
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 393 AA

Restrictions For Research Use only

Stockage

Détail du produit anti-p53 anticorps Détail du antigène p53 Information d'application References for anti-p53 antibody (ABIN2779317) Images Haut de la page
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-p53 antibody (ABIN2779317)

Détail du produit anti-p53 anticorps Détail du antigène p53 Information d'application Stockage Images Haut de la page
Background publications

Boehme, Kulikov, Blattner: "p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 22, pp. 7785-90, 2008

Images

Détail du produit anti-p53 anticorps Détail du antigène p53 Information d'application Stockage References for anti-p53 antibody (ABIN2779317) Haut de la page
Supplier Images
Immunohistochemistry (IHC) image for anti-Tumor Protein P53 (TP53) (N-Term) antibody (ABIN2779317) anti-Tumor Protein P53 (TP53) (N-Term) antibody
Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) (N-Term) antibody (ABIN2779317) Host: Rabbit
Target Name: TP53
Sample Tissue: Human Fetal Liver
...
Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) (N-Term) antibody (ABIN2779317) Host: Rabbit
Target Name: TP53
Sample Tissue: Human Adult Placenta