anti-Mouton p53 anticorps pour Western Blotting

Recommended p53 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Tumor Protein P53 (TP53) Anticorps
  • BCC7
  • LFS1
  • P53
  • TRP53
  • p53
  • Trp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • tp53
  • Xp53
  • TP53
  • tumor protein p53
  • cellular tumor antigen p53
  • transformation related protein 53
  • tumor protein p53 L homeolog
  • TP53
  • CpipJ_CPIJ002758
  • Tp53
  • tp53
  • Trp53
  • tp53.L
Épitope
N-Term
187
120
89
86
77
74
69
60
58
54
51
45
45
44
43
34
34
34
25
23
22
22
22
22
17
15
15
15
15
15
14
14
14
13
12
11
11
11
10
9
9
8
8
8
8
7
7
7
7
7
7
6
6
6
6
6
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Boeuf (Vache), Cobaye, Cheval, Humain, Porc, Lapin, Rat (Rattus), Mouton
2622
567
480
286
155
120
118
87
53
22
22
19
18
16
15
13
6
4
4
4
3
3
2
2
1
1
Hôte
Lapin
1489
1263
7
1
1
1
1
Clonalité
Polyclonal
Conjugué
Cet anticorp p53 est non-conjugé
88
85
74
61
54
46
45
35
32
31
31
25
25
25
25
24
24
24
20
19
18
15
15
14
14
14
14
14
12
8
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
6
5
2
2
2
Application
Western Blotting (WB)
2149
955
884
770
751
750
433
325
317
179
110
90
75
41
34
17
17
15
13
13
4
4
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Options
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N° du produit ABIN2777951
$ 289.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
3.1681855 ABIN2779317 ChIP IHC WB Rabbit N-Term Connectez-vous pour afficher Polyclonal 1
3.1681855 ABIN2779979 WB Rabbit C-Term Connectez-vous pour afficher Polyclonal 1
1 ABIN574482 IHC IHC (p) WB Rabbit N-Term Connectez-vous pour afficher Polyclonal 0
1 ABIN202409 WB Rabbit IgG AA 281-330 Connectez-vous pour afficher Polyclonal 0
1 ABIN467883 WB Rabbit N-Term Connectez-vous pour afficher Polyclonal 0
1 ABIN320175 EIA IHC (fro) IHC (p) IP WB Mouse IgG2a AA 20-25 Connectez-vous pour afficher DO-1 4
1 ABIN120054 EIA IHC (fro) IHC (p) IP WB Mouse IgG2a AA 20-25 Connectez-vous pour afficher DO-1 3

General

Antigène Tumor Protein P53 (TP53) Anticorps
Épitope N-Term
(187), (120), (89), (86), (77), (74), (69), (60), (58), (54), (51), (45), (45), (44), (43), (34), (34), (34), (25), (23), (22), (22), (22), (22), (17), (15), (15), (15), (15), (15), (14), (14), (14), (13), (12), (11), (11), (11), (10), (9), (9), (8), (8), (8), (8), (7), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Boeuf (Vache), Cobaye, Cheval, Humain, Porc, Lapin, Rat (Rattus), Mouton
(2622), (567), (480), (286), (155), (120), (118), (87), (53), (22), (22), (19), (18), (16), (15), (13), (6), (4), (4), (4), (3), (3), (2), (2), (1), (1)
Hôte Lapin
(1489), (1263), (7), (1), (1), (1), (1)
Clonalité
Polyclonal
Conjugué Cet anticorp p53 est non-conjugé
(88), (85), (74), (61), (54), (46), (45), (35), (32), (31), (31), (25), (25), (25), (25), (24), (24), (24), (20), (19), (18), (15), (15), (14), (14), (14), (14), (14), (12), (8), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (6), (5), (2), (2), (2)
Application Western Blotting (WB)
(2149), (955), (884), (770), (751), (750), (433), (325), (317), (179), (110), (90), (75), (41), (34), (17), (17), (15), (13), (13), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 1 référence disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-p53 anticorps

Détail du antigène p53 Information d'application Stockage References for anti-p53 antibody (ABIN2777951) Images
Blocking Peptide Blocking peptide for this product available: ABIN985387
Séquence EEPQSDPSVE PPLSQETFSD LWKLLPENNV LSPLPSQAMD DLMLSPDDIE
Homologie Cow: 100%, Guinea Pig: 86%, Horse: 90%, Human: 100%, Pig: 100%, Rabbit: 86%, Rat: 86%, Sheep: 100%
Attributs du produit This is a rabbit polyclonal antibody against TP53. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Immunogène The immunogen is a synthetic peptide directed towards the N terminal region of human TP53
Plasmids, Primers & others

Détail du antigène p53

Détail du produit anti-p53 anticorps Information d'application Stockage References for anti-p53 antibody (ABIN2777951) Images Haut de la page
Antigène
Autre désignation TP53 (TP53 Antibody Extrait)
Sujet TP53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Alias Symbols: LFS1, TRP53, p53
Protein Size: 393
Poids moléculaire 44 kDa
ID gène 7157
NCBI Accession NM_000546, NP_000537
UniProt P04637
Pathways Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy

Information d'application

Détail du produit anti-p53 anticorps Détail du antigène p53 Stockage References for anti-p53 antibody (ABIN2777951) Images Haut de la page
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 393 AA

Restrictions For Research Use only

Stockage

Détail du produit anti-p53 anticorps Détail du antigène p53 Information d'application References for anti-p53 antibody (ABIN2777951) Images Haut de la page
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-p53 antibody (ABIN2777951)

Détail du produit anti-p53 anticorps Détail du antigène p53 Information d'application Stockage Images Haut de la page
Background publications

Boehme, Kulikov, Blattner: "p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 22, pp. 7785-90, 2008

Images

Détail du produit anti-p53 anticorps Détail du antigène p53 Information d'application Stockage References for anti-p53 antibody (ABIN2777951) Haut de la page
Images (Fournisseur)
Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) (N-Term) antibody (ABIN2777951) WB Suggested Anti-TP53 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Posit...
Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) (N-Term) antibody (ABIN2777951) Sample Type: 1. and 2. Human Cystic Fibrosis Bronchial Epithelial Cells (35ug)...