anti-CDK5 Anticorps

270 Cyclin-Dependent Kinase 5 (CDK5) Anticorps de 27 fabricants sont disponibles sur www.anticorps-enligne.fr.

Qualité de données
  • 9
  • 79
Type
  • 270
    Primaire
Antigène
  • 270
Réactivité
  • 263
  • 172
  • 163
  • 19
  • 18
Application
  • 213
  • 103
  • 53
  • 36
  • 34
Hote
  • 200
  • 70
Clonalité
  • 203
  • 67
Clone
  • 6
  • 4
  • 4
  • 3
  • 2
Epitope
  • 41
  • 17
  • 17
  • 15
  • 14
Conjugué
  • 197
  • 12
  • 7
  • 6
  • 6
Isotype
  • 136
  • 27
  • 14
  • 5
  • 3
Format
  • 194
  • 15
Suggested next Filters
270 Produits
Mouse, Monoclonal (4-00E-04), IgG1
ReactivitéHumain, Rat (Rattus), Singe
Application ICC, FACS, IHC, ELISA, WB
Détails de la commande Cat. No. ABIN969041
$430.10
100 μL
Plus shipping costs $45.00
Envoi sous 3 à 4 jours ouvrables
ReactivitéHumain, Souris
Application FACS, IF, ELISA, WB
Détails de la commande Cat. No. ABIN3030614
$452.38
Plus shipping costs $45.00
Envoi sous 2 à 3 jours ouvrables
Mouse, Monoclonal (4E4), IgG1
ReactivitéHumain
Application ELISA, FACS, IF, IHC (p), WB
Détails de la commande Cat. No. ABIN5575058
$460.00
100 μL
Plus shipping costs $45.00
Envoi sous 11 à 12 jours ouvrables
Mouse, Monoclonal (4-00E-004), IgG1
ReactivitéHumain, Singe, Rat (Rattus)
Application EIA, IF, IHC (p), WB
Détails de la commande Cat. No. ABIN1106648
$495.00
0.1 mL
Plus shipping costs $45.00
Envoi sous 6 à 8 jours ouvrables
Mouse, Monoclonal (40000), IgG1
ReactivitéHumain
Application ELISA, FACS, IF, IHC, IHC (p), WB
Détails de la commande Cat. No. ABIN1497425
$551.83
100 μL
Plus shipping costs $45.00
Envoi sous 11 à 14 jours ouvrables
ReactivitéBoeuf (Vache), Chien, Cobaye, Cheval, Humain, Souris, Porc, Lapin, Rat (Rattus), Mouton, Yeast (Saccharomyces cerevisiae), Poisson zèbre (Danio rerio)
Application IHC, WB
Détails de la commande Cat. No. ABIN2780626
$229.00
100 μL
Plus shipping costs $45.00
Envoi sous 2 à 3 jours ouvrables
ReactivitéHumain, Souris, Rat (Rattus)
Application IF (p), IHC (p), WB
Détails de la commande Cat. No. ABIN670101
$339.90
100 μL
Plus shipping costs $45.00
Envoi sous 3 à 7 jours ouvrables
ReactivitéRat (Rattus), Souris, Humain
Application WB
Détails de la commande Cat. No. ABIN1574122
$160.67
40 μg
Plus shipping costs $45.00
Envoi sous 2 à 3 jours ouvrables
ReactivitéHumain, Souris, Rat (Rattus)
Application IHC, ELISA, WB
Détails de la commande Cat. No. ABIN1848070
$323.60
Plus shipping costs $45.00
Envoi sous 11 à 16 jours ouvrables
ReactivitéHumain
Application IP, WB
Détails de la commande Cat. No. ABIN514281
$350.67
100 μL
Plus shipping costs $45.00
Envoi sous 11 à 12 jours ouvrables
ReactivitéHumain
Application IF, WB
Détails de la commande Cat. No. ABIN514280
$364.00
50 μg
Plus shipping costs $45.00
Envoi sous 11 à 12 jours ouvrables
ReactivitéHumain, Singe, Souris, Rat (Rattus)
Application ELISA, ICC, IF, WB
Détails de la commande Cat. No. ABIN6255818
$390.77
Plus shipping costs $45.00
Envoi sous 11 à 12 jours ouvrables
ReactivitéHumain, Singe, Souris, Rat (Rattus)
Application ELISA, ICC, IF, WB
Détails de la commande Cat. No. ABIN6271896
$450.00
Plus shipping costs $45.00
Envoi sous 11 à 12 jours ouvrables
ReactivitéHumain, Souris
Application FACS, ELISA, WB
Détails de la commande Cat. No. ABIN3028603
$452.38
Plus shipping costs $45.00
Envoi sous 2 à 3 jours ouvrables
ReactivitéHumain, Rat (Rattus), Singe
Application ELISA, FACS, IF/ICC, IHC, WB
Détails de la commande Cat. No. ABIN1843134
$464.30
100 μL
Plus shipping costs $45.00
Envoi sous 11 à 16 jours ouvrables
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CDK5 profil antigène

Profil protéine

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocytes differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and PCTAIRE 1/CDK16 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity\; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicites cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells\; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling.

Alternative names and synonyms associated with CDK5

  • cyclin dependent kinase 5 (CDK5) anticorps
  • cyclin-dependent kinase 5 (Cdk5) anticorps
  • Cyclin-dependent kinase 5 (Cdk5) anticorps
  • cyclin-dependent kinase 5 (cdk5) anticorps
  • cyclin-dependent kinase 5 L homeolog (cdk5.L) anticorps
  • cyclin dependent kinase 5 (Cdk5) anticorps
  • Cyclin-dependent-like kinase 5 (cdk-5) anticorps
  • AW048668 anticorps
  • cdk5 anticorps
  • CG8203 anticorps
  • Crk6 anticorps
  • DmCdk5 anticorps
  • Dmel\\CG8203 anticorps
  • PSSALRE anticorps
  • zgc:101604 anticorps

Protein level used designations for CDK5

TPKII catalytic subunit , cell division protein kinase 5 , protein kinase CDK5 splicing , serine/threonine-protein kinase PSSALRE , tau protein kinase II catalytic subunit , CR6 protein kinase , CG8203-PA , Cdk5-PA , PDPK , proline-directed protein kinase 33 kDa subunit , neuronal cyclin-dependent kinase 5 , Cell division protein kinase 5 , cyclin-dependent-like kinase 5

GENE ID SPECIES
1020 Homo sapiens
12568 Mus musculus
36727 Drosophila melanogaster
140908 Rattus norvegicus
281066 Bos taurus
65234 Danio rerio
399296 Xenopus laevis
100190948 Gallus gallus
475537 Canis lupus familiaris
100732840 Cavia porcellus
100190973 Ovis aries
733700 Sus scrofa
100352775 Oryctolagus cuniculus
176774 Caenorhabditis elegans
101865873 Macaca fascicularis