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anti-Human FOXO3 Anticorps:
anti-Rat (Rattus) FOXO3 Anticorps:
anti-Mouse (Murine) FOXO3 Anticorps:
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Human FOXO3 Primary Antibody pour IHC - ABIN966150
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. dans The Journal of cell biology 2005
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Human Polyclonal FOXO3 Primary Antibody pour IHC - ABIN966151
Essafi, Fernández de Mattos, Hassen, Soeiro, Mufti, Thomas, Medema, Lam: Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. dans Oncogene 2005
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Human Polyclonal FOXO3 Primary Antibody pour ICC, IF - ABIN152045
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. dans Molecular pharmaceutics 2015
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Human Polyclonal FOXO3 Primary Antibody pour IF, IHC - ABIN1355835
Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. dans Cell 2006
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Human Polyclonal FOXO3 Primary Antibody pour ChIP, ICC - ABIN4312377
Sinanoglu, Yener, Ekici, Midi, Aksungar: The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. dans Urology 2012
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Human Polyclonal FOXO3 Primary Antibody pour IF (p), IHC (p) - ABIN731168
Morales, Abrigo, Acuña, Santos, Bader, Brandan, Simon, Olguin, Cabrera, Cabello-Verrugio: Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. dans Disease models & mechanisms 2016
Dog (Canine) Polyclonal FOXO3 Primary Antibody pour ELISA, WB - ABIN2473689
Dijkers, Birkenkamp, Lam, Thomas, Lammers, Koenderman, Coffer: FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. dans The Journal of cell biology 2002
Human Polyclonal FOXO3 Primary Antibody pour ICC, IF - ABIN152044
Yuan, Luo, Liu, Lou: Regulation of SIRT1 activity by genotoxic stress. dans Genes & development 2012
A better understanding of the mechanisms regulating the FOXO3-FOXM1 (Montrer FOXM1 Anticorps) axis, as well as their downstream transcriptional targets and functions, may render these proteins reliable and early diagnostic/prognostic factors as well as crucial therapeutic targets for cancer treatment and importantly, for overcoming chemotherapeutic drug resistance.
the inhibition of miR (Montrer MLXIP Anticorps)-9 could induce apoptosis in cervical cancer by targeting FOXO3.
Study in three European populations present experimental evidence for a functional link between common intronic variants in FOXO3 and human longevity.
circRNA-FOXO3 expression was decreased in NSCLC cells and tissue samples. It can inhibit the development of NSCLC cells as a ceRNA through sponging miR (Montrer MLXIP Anticorps)-155 and releasing FOXO3 level.
The protein expression levels of several autophagy makers, such as LC3I, LC3II and Beclin-1 (Montrer BECN1 Anticorps), were higher in FOXO3 plasmid-transfected AGS (Montrer JAG1 Anticorps) cells cultured in an acidic microenvironment than in control cells, while P62 (Montrer GTF2H1 Anticorps) protein expression levels were clearly decreased in FOXO3 plasmid-transfected cells compared with control cells.
Study suggests that miR (Montrer MLXIP Anticorps)-487a-3p might repress CTLA4 (Montrer CTLA4 Anticorps) and FOXO3 by binding to their 3'UTRs and contribute to the development of T1D.
Findings determined that the crucial regions corresponding to the SP1 (Montrer PSG1 Anticorps) binding sites located between 2,000 and 1,037 bp were essential for FoxO3a transcriptional activity. Furthermore, FoxO3a transcription was upregulated in response to hypoxic and oxidative stress in colorectal tumor cells (CRC (Montrer CALR Anticorps)), indicating that the interaction between SP1 (Montrer PSG1 Anticorps) and FoxO3a may have important implications in CRC (Montrer CALR Anticorps) progression.
FOXO3a expression correlated with adverse clinicopathological features, such as lymph node metastasis, perineural invasion and higher Ki-67 (Montrer MKI67 Anticorps) proliferation index in triple-negative breast cancers.
human FOXO3B locus encodes a bona fide human gene; unlike FOXO3A, FOXO3B is cytosolically localized in both the presence and absence of active Akt (Montrer AKT1 Anticorps)
FoxO3a overexpression increased the transcription and protein expression of Bcl2like protein 11 and cyclindependent kinase inhibitor 1B, and inhibited cyclin D1 (Montrer CCND1 Anticorps) transcription and expression.
AIM1 and FOXO3 genes were found to be associated with NBA (number born alive); these genes increase ovarian reproductive capacity and follicle number and decrease gonadotropin levels.
These results indicate that myostatin (Montrer MSTN Anticorps) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (Montrer NR3C1 Anticorps) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (Montrer AKT1 Anticorps) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL (Montrer VHL Anticorps), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
AMPK (Montrer PRKAA1 Anticorps) stabilizes FOXO3 and suggest a role in the first initiation step of mitochondrial segregation in muscle cells.
Data indicate a key role of FoxO3a/Zdhhc3 (Montrer ZDHHC3 Anticorps)/GluA1 (Montrer GRIA1 Anticorps) axis in the high-fat diet (HFD)-dependent impairment of cognitive function.
Taken together, these data implicate Foxo3 and its transcriptional targets in outer hair cell survival after noise damage.
These results reveal mechanisms by which FoxO3a promotes host survival during infection with chronic, virulent intracellular bacteria.
findings demonstrate that the mTORC2 (Montrer CRTC2 Anticorps)/AKT (Montrer AKT1 Anticorps)/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.
Melanoma dormancy in a mouse model is linked to GILZ (Montrer TSC22D3 Anticorps)/FOXO3A-dependent quiescence of disseminated stem-like cells
data showed that Klotho (Montrer KL Anticorps) protects Tac (Montrer IL2RA Anticorps)-induced oxidative stress by negatively regulating the PI3K/AKT (Montrer AKT1 Anticorps) pathway and subsequently enhancing FoxO3a-mediated MnSOD (Montrer SOD2 Anticorps) expression.
miR (Montrer MLXIP Anticorps)-34a might suppress the excessive autophagic activity in alveolar type II epithelial AT-II cells via targeting FoxO3 to reduce the damage of LPS (Montrer TLR4 Anticorps)-induced Acute Lung Injury.
PPE effectively attenuated oxidative stress and ototoxicity by regulating FoxO3a, and may thus prove to be beneficial in protecting auditory cells from ototoxic drugs.
Results show that Foxo3a is depressed in the nucleus while autophagy is impaired, and NLRP3 (Montrer NLRP3 Anticorps) inflammasome is activated in Kupffer cells (KCs). Over-expression of Foxo3a restores autophagy flux and attenuates activation of the NLRP3 (Montrer NLRP3 Anticorps) inflammasome via promoting the transcription of Bim (Montrer BCL2L11 Anticorps).
NO/protein kinase (Montrer CDK7 Anticorps) G (PKG (Montrer PRKG1 Anticorps))-dependent downregulation of PGC-1 alpha and the ROS (Montrer ROS1 Anticorps) detoxification system in endothelial cells are mediated by the PI3K/Akt (Montrer AKT1 Anticorps) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (Montrer ROS1 Anticorps)-induced apoptosis in mammalian cells.
FOXO1 (Montrer FOXO1 Anticorps), 3, and 4 as well as their upstream regulator, AKT/p-AKT (Montrer AKT1 Anticorps), was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like