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anti-Human FOXO3 Anticorps:
anti-Rat (Rattus) FOXO3 Anticorps:
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Human FOXO3 Primary Antibody pour IHC - ABIN966150
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. dans The Journal of cell biology 2005
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Human Polyclonal FOXO3 Primary Antibody pour IHC - ABIN966151
Essafi, Fernández de Mattos, Hassen, Soeiro, Mufti, Thomas, Medema, Lam: Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. dans Oncogene 2005
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Human Polyclonal FOXO3 Primary Antibody pour IF, IHC - ABIN1355835
Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. dans Cell 2006
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Human Polyclonal FOXO3 Primary Antibody pour ICC, IF - ABIN152045
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. dans Molecular pharmaceutics 2015
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Human Polyclonal FOXO3 Primary Antibody pour ChIP, ICC - ABIN4312377
Sinanoglu, Yener, Ekici, Midi, Aksungar: The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. dans Urology 2012
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Human Polyclonal FOXO3 Primary Antibody pour IF (p), IHC (p) - ABIN731168
Morales, Abrigo, Acuña, Santos, Bader, Brandan, Simon, Olguin, Cabrera, Cabello-Verrugio: Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. dans Disease models & mechanisms 2016
Human Polyclonal FOXO3 Primary Antibody pour ICC, IF - ABIN152044
Yuan, Luo, Liu, Lou: Regulation of SIRT1 activity by genotoxic stress. dans Genes & development 2012
Human Polyclonal FOXO3 Primary Antibody pour ELISA, WB - ABIN250244
Brunet, Bonni, Zigmond, Lin, Juo, Hu, Anderson, Arden, Blenis, Greenberg: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. dans Cell 1999
Dog (Canine) Polyclonal FOXO3 Primary Antibody pour ELISA, WB - ABIN2473689
Dijkers, Birkenkamp, Lam, Thomas, Lammers, Koenderman, Coffer: FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. dans The Journal of cell biology 2002
Cytoplasmic retention of FOXO3a may represent a potential biomarker for response to combined treatment with inhibitors of PI3K (Montrer PIK3CA Anticorps) and autophagy in PIK3CA (Montrer PIK3CA Anticorps)-mutant cervical cancer cells.
Results show that FOXO3-phosphorylation at threonine-32 (T32) and nuclear localization in neuroblastoma (Montrer ARHGEF16 Anticorps) biopsies significantly correlated with stage IV disease. Data suggest that, depending on the mode and intensity of activation, cellular FOXO3 acts as a homeostasis regulator promoting tumor growth at hypoxic conditions and tumor angiogenesis in high-stage neuroblastoma (Montrer ARHGEF16 Anticorps).
FoxO3a might be a key regulator in cetuximab resistance through up-regulating c-Myc (Montrer MYC Anticorps) in colorectal cancer targeted therapy.
Atorvastatin strengthens Skp2 binding to FOXO1 or ICAM1, leading to ubiquitination and degradation. Skp2-dependent ubiquitination of major pathogenic molecules is the key mechanism for statin's protective effect on endothelial function in diabetes.
Transcriptional factor PAX3 (PAX3 (Montrer PAX3 Anticorps)) exerted its tumor suppressor function by inhibiting the activity of major signaling pathways and enhancing expression and activity of transcription factor forkhead box O3 protein (FOXO3a).
The result suggests that FOXO3 rs12212067 polymorphism does not play an important role in susceptibility to T. cruzi infection and/or chronic Chagas cardiomyopathy.
Overexpression of circ-Foxo3 decreased the interaction between Foxo3 and MDM2 (Montrer MDM2 Anticorps), and repressed the function of MDM2 (Montrer MDM2 Anticorps) in modulating poly-ubiquitination of Foxo3.
silencing FOXO3 diminishes bepridil- and trifluoperazine-induced apoptosis in triple-negative breast cancer cells
Combined treatment with gamma-irradiation (gammaIR) and a dual PI3K (Montrer PIK3CA Anticorps)/mTOR (Montrer FRAP1 Anticorps) inhibitor causes loss of stemness and of FoxO1 (Montrer FOXO1 Anticorps)/3 proteins in p53 (Montrer TP53 Anticorps)-proficient glioblastoma multiforme stem cells (GBM-SCs (Montrer TWIST1 Anticorps)).
The authors found that transient TUBB3 (Montrer TUBB3 Anticorps) activation, through ABCB1 (Montrer ABCB1 Anticorps), in response to the stimulation of FOXO3a expression, significantly contributes to the cross-resistance of the paclitaxel-resistant cell population and consequently limits the efficacy of both agents where cancer cells have developed multiple resistance.
These results indicate that myostatin (Montrer MSTN Anticorps) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (Montrer NR3C1 Anticorps) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (Montrer AKT1 Anticorps) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL (Montrer VHL Anticorps), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
Results show that Foxo3a is depressed in the nucleus while autophagy is impaired, and NLRP3 (Montrer NLRP3 Anticorps) inflammasome is activated in Kupffer cells (KCs). Over-expression of Foxo3a restores autophagy flux and attenuates activation of the NLRP3 (Montrer NLRP3 Anticorps) inflammasome via promoting the transcription of Bim (Montrer BCL2L11 Anticorps).
Data indicate that forkhead box O3 (FoxO3) has a central role in the neuronal reprogramming susceptibility of cells, and the importance of FoxO3 appears to change during development.
These results suggest that lack of FXR (Montrer NR1H4 Anticorps) impaired FoxO3a-mediated autophagy and in turn exacerbated alcohol-induced liver injury
pro-apoptotic role of miR (Montrer MLXIP Anticorps)-34a in PA-induced cholangiocyte lipoapoptosis in culture and in the liver
data show that the GSK3B-FOXO3 pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R (Montrer IGF1R Anticorps) after partial hepatectomy.
BIM (Montrer BCL2L11 Anticorps)-dependent death during CD8 (Montrer CD8A Anticorps)(+) T-cell deletion is FOXO3 independent.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (Montrer MUL1 Anticorps) FBXO32/atrogin-1 (Montrer FBXO32 Anticorps) and its transcription factor FOXO3A.
MiR (Montrer MLXIP Anticorps)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.
NO/protein kinase (Montrer CDK7 Anticorps) G (PKG (Montrer PRKG1 Anticorps))-dependent downregulation of PGC-1 alpha and the ROS (Montrer ROS1 Anticorps) detoxification system in endothelial cells are mediated by the PI3K/Akt (Montrer AKT1 Anticorps) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (Montrer ROS1 Anticorps)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like