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anti-Human ERBB2IP Anticorps:
anti-Mouse (Murine) ERBB2IP Anticorps:
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Human Polyclonal ERBB2IP Primary Antibody pour ICC, IF - ABIN4309327
Li, Zhou, Li, Wu, Liu, Zhao, Jia, Sun: Inhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine. dans Neoplasia (New York, N.Y.) 2017
Erbin interacted with kinase suppressor of Ras 1 (KSR1) and displaced it from the RAF/MEK/ERK complex to prevent signal propagation..These findings establish the scaffold protein Erbin as a negative regulator of EMT and tumorigenesis in colorectal cancer through direct suppression of Akt and RAS/RAF signaling
Erbb2 interacting protein (ERBB2IP), a known target of miR-23c, was positively regulated by KTN1-AS1.
miR-23c inhibited cell proliferation and accelerated apoptosis by attenuating ERBB2IP.
Our data uncovered an important role of Erbin in regulating hepatocellular carcinoma (HCC) tumorigenesis through inactivating ERalpha-mediated tumor-suppressive signaling, suggesting a new strategy for tamoxifen therapy in HCC by targeting Erbin/ERalpha signaling axis.
STAT3 activation promotes ERBIN expression and negatively regulates TGF-beta activity by the formation of a STAT3-ERBIN-SMAD2/3 complex.
Erbin loss accelerates cell cycle though down-regulating p21 and p27 expression. Erbin is a novel negative modulator of Akt1-Skp2-p27 signaling pathway.
Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor
Erbin is an ErbB2 regulator for breast tumor formation and progression
analysis of the C-terminal ligand specificity of the erbin PDZ domain
Data suggest that Erbin can interact with Sema4C, and co-expression of Erbin blocks the process of Sema4C-induced epithelial-mesenchymal transition.
Data reveal that Erbin is a negative regulator of AKT activation and suggest that Erbin may play a role in breast cancer progression.
DSG1 and Erbin cooperate to repress MAPK signaling and promote keratinocyte differentiation.
These results unravel a critical role of c-Myb in promoting Erbin transcription in G2/M phase and also predict an unappreciated function of Erbin in cell cycle progression.
Data conclude that LAP2 is widely overexpressed in diverse digestive tract cancers and LAP2beta regulates motility of cancer cells and suggest that LAP2beta may have utility for diagnostics and therapeutics in digestive tract cancers.
ERBIN binds to SARA using a domain (amino acids 1208-1265) that also interacts with SMAD2 and SMAD3, which we have called the SSID (SARA- and SMAD-interacting domain)
PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF
interacts in vivo with p0071 and may be involved in the organization of adherens junctions and the desmosomes of epithelia
Erbin is a novel suppressor of Ras signaling by disrupting the Ras-Raf interaction; a negative regulator of the Ras-Raf-Erk signaling pathway
selective binding and sequestration of this residue in its unphosphorylated state by the Erbin PDZ provides a novel mechanism for regulation of the ErbB2-mediated signaling and oncogenicity
In this review, erbin is shown to inhibit epidermal growth factor signaling by preventing the activation of the Raf-1 kinase by Ras.
Tumor organoids derived from Erbin/Apc double knockout mice displayed increased tumor initiation potential and activation of Wnt signaling
Overexpression of FHL2 alone had no effect on Erbin expression, but in the presence of MITF, Erbin expression was decreased.
By degrading Erbin and Nrf2, Sag activates the Ras-Raf pathway and causes ROS accumulation to trigger autophagy and senescence
Results support that hyperglycemia may impair NRG1/Erb B2 signaling by disrupting the balance between NRG1 isoforms, decreasing the expression of erbin and correspondingly activating the MAPK pathway
Erbin is an inhibitor of pathological cardiac hypertrophy.
These observations demonstrate a crucial function for Erbin in AMPAR surface expression in cortical parvalbumin positive interneurons
This study demonistrated that demonstrate that Erbin is required for remyelination of regenerated axons after injury, probably by regulating ErbB2 and NRG1 levels, identifying a novel player in regulating remyelination.
preliminary characterization of its interaction with Smad3
erbin regulates MAP kinase activation in Schwann cells and suggest that erbin links merlin to both adherens junction protein complexes and the MAP kinase signaling pathway.
Erbin is a regulator of Nod2-dependent NF-kappaB signaling with a role in inflammatory responses
Erbin has a regulatory role in the Ras-Raf-MEK pathway and may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction
These observations indicate a critical role of Erbin in myelination and identify a regulatory mechanism of NRG1 signaling.
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, protein LAP2
, erbb2 interacting protein
, ERBB2 interacting protein
, protein LAP2-like
, erbb2-interacting protein
, similar to Erbb2 interacting protein isoform 2