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Study provided the first link between energy homeostasis, lipid metabolism and pro-opiomelanocortin (POMC (Montrer POMC Kits ELISA)) neuronal IRE1alpha function. The effects of POMC (Montrer POMC Kits ELISA) IRE1alpha knockout were mediated via increased thermogenesis, possibly caused by the increased alpha-MSH production in the hypothalamus. These results demonstrate that IRE1alpha in POMC (Montrer POMC Kits ELISA) neurons plays a critical role in the regulation of obesity and obesity-related m...
Data show that LPS (Montrer TLR4 Kits ELISA) induces endoplasmic reticulum (ER) stress and P300 (Montrer NOTCH1 Kits ELISA) activity via the XBP1 (Montrer XBP1 Kits ELISA)/IRE1 pathway.
cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner.
Data suggest that activation of GRP78 (Montrer HSPA5 Kits ELISA)/Ire1/Xbp1 (Montrer XBP1 Kits ELISA) pathway of ER stress-unfolded protein response is involved in mouse decidualization.
Fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of this stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal levels.
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.
defective autophagy in intestinal epithelial cells (IECs) may predispose to Crohn's disease ileitis via impaired clearance of IRE1alpha aggregates during ER stress at this site.
The findings indicate that IRE1-XBP1 (Montrer XBP1 Kits ELISA) downregulation distinguishes germinal center B-cell-like diffuse large B-cell lymphoma (DLBCL) from other DLBCL subtypes and contributes to tumor growth.
the ABL (Montrer ABL1 Kits ELISA) family of tyrosine kinases rheostatically enhances IRE1alpha's enzymatic activities, thereby potentiating endoplasmic reticulum stress-induced apoptosis.
We reveal distinct binding affinities between the binary and ternary complexes thus formed, that suggest a preference for the PERK (Montrer EIF2AK3 Kits ELISA) signaling branch under stress, and a predilection for the GRP78 (Montrer HSPA5 Kits ELISA)-UPR sensor complex formation upon stressor removal. These results imply a gated UPR mechanism that tunes the overall cellular behavior to the accumulation of unfolded proteins.
The present study is the first to uncover a key prosurvival modulator, Yip1A, which coordinates IRE1 signaling with PERK signaling to support the survival of HeLa and CaSki cervical cancer cells.
Overall, these data demonstrate that hypoxia can suppress adiponectin expression and activate the PERK and IRE1 signaling pathways in differentiated adipocytes, and this two pathways are involved in the suppression of adiponectin expression induced by hypoxia.
ER stress-regulated IRE1 dependent decay is involved in regulation of hepatic diseases. (review)
The unfolded protein response reduces glucose metabolism via IRE1 signaling.
Results of this investigation demonstrate that inhibition of IRE1 signaling enzyme function affects the expression of NRIP1 (Montrer NRIP1 Kits ELISA), EBBP (Montrer TRIM16 Kits ELISA), ESRRA (Montrer ESRRA Kits ELISA), E2IG5 (Montrer FAM162A Kits ELISA), PGRMC2 (Montrer PGRMC2 Kits ELISA), and SLC39A6 (Montrer SLC39A6 Kits ELISA) genes in U87 glioma cells in gene specific manner and these changes possibly contribute to the suppression of the cell proliferation. Most of these genes are regulated by hypoxia and preferentially through IRE1 signaling pathway of endoplasmic reticulum stress
IRE1alpha was shown to cleave miR (Montrer MLXIP Kits ELISA)-150 and thereby to release the suppressive effect that miR (Montrer MLXIP Kits ELISA)-150 exerted on alphaSMA (Montrer ACTA2 Kits ELISA) expression through c-Myb (Montrer MYB Kits ELISA). Inhibition of IRE1alpha was also demonstrated to block endoplasmic reticulum expansion through an XBP-1 (Montrer XBP1 Kits ELISA)-dependent pathway.
IRE-1 has an ancient function as a cytoplasmic sentinel that activates p38 (Montrer CRK Kits ELISA) and SKN-1(Nrf2 (Montrer GABPA Kits ELISA)). csteine modifications induced by ROS (Montrer ROS1 Kits ELISA) signals can direct proteins to adopt unexpected functions and may coordinate many cellular processes.
Western blot analysis of subcutaneously implanted AsPC-1 and BxPC-3 tumors as well as orthotopically implanted Panc-1 tumors demonstrated upregulation of BIP (Montrer GDF10 Kits ELISA), CHOP (Montrer DDIT3 Kits ELISA), and IRE1alpha expression in the tumor lysates from penfluridol-treated mice as compared to tumors from control mice
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.
endoplasmic reticulum-to-nucleus signaling 1
, inositol-requiring 1 alpha
, inositol-requiring protein 1
, serine/threonine-protein kinase/endoribonuclease IRE1
, endoplasmic reticulum-to-nucleus signaling 2
, inositol-requiring 1 (Yeast homologue)
, inositol-requiring 1 beta
, inositol-requiring protein 2
, serine/threonine-protein kinase/endoribonuclease IRE2
, ER to nucleus signalling 1
, inositol-requiring 1
, inositol-requiring enzyme 1
, protein kinase/endoribonuclease
, endoplasmic reticulum (ER) to nucleus signalling 1
, endoplasmic reticulum to nucleus signalling 1