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Human Polyclonal CLDN4 Primary Antibody pour IF (p), IHC (p) - ABIN680743
Wang, Chen, Liang, Yan, Lin, Liu, Luo, Huang, Li, Liu, Tang: Notch inhibition promotes fetal liver stem/progenitor cells differentiation into hepatocytes via the inhibition of HNF-1?. dans Cell and tissue research 2014
Human Monoclonal CLDN4 Primary Antibody pour FACS - ABIN4895293
Shim, Kim, Jin, Kim, Oh: Claudin 4-targeted nanographene phototherapy using a Clostridium perfringens enterotoxin peptide-photosensitizer conjugate. dans Acta pharmacologica Sinica 2018
these results suggest that Helicobacter pylori lipopolysaccharide induces TLR2 expression in the gastric adenocarcinoma cells, and that the longer the exposure to lipopolysaccharide, the greater the expression of TLR2 in the cell membrane; consequently the expression of claudin-4, -6, -7 and -9 also increases
HIF-1alpha (Montrer HIF1A Anticorps) expression was upregulated in the vasculogenic mimicry-positive CRC (Montrer CALR Anticorps) cell line HCT-116 and thereby affected the expression of the EMT (Montrer ITK Anticorps)-related markers Claudin-4, E-cadherin (Montrer CDH1 Anticorps) (E-cd) and Vimentin(VIM (Montrer VIM Anticorps)).
expression of claudin-4 is highly specific for true epithelial differentiation and may be useful to distinguish SWI (Montrer SMARCA1 Anticorps)/SNF (Montrer SNRPA Anticorps) complex-deficient undifferentiated carcinomas from sarcomas with epithelioid morphology. The lack of claudin-4 expression in ovarian small cell carcinomas of hypercalcemic type suggests that these tumors may be better regarded as sarcomas rather than carcinomas.
Data indiate a regulatory network in gastric cancer whereby claudin-4 expression is reduced by specific miRNAs, which are in turn bound by specific lncRNAs acting as competing endogenous RNAs (ceRNAs), resulting in increased claudin-4 expression.
This is the first study to show how TGF-beta (Montrer TGFB1 Anticorps) regulates the expression of Claudin-4 through c-Jun (Montrer JUN Anticorps) signaling and how this pathway contributes to the migratory and tumorigenic phenotype of lung tumor cells.
Claudin-4 functionally contributes to both ovarian tumor cell apoptosis resistance and migration and targeting extracellular loop interactions of claudin-4 may have therapeutic implications for reducing ovarian tumor burden.
Fluorescence-based flow cytometry and xenon magnetic resonance imaging (MRI (Montrer C7ORF49 Anticorps)) indicate binding of the biosensor specifically to claudin 4 (Cldn4)-expressing cells.
Studies indicate that Grainyhead-like transcription factor 2 (Montrer HNF1B Anticorps) (GRHL2 (Montrer GRHL2 Anticorps)) controls the expression of E-cadherin (CDH1 (Montrer CDH1 Anticorps)) required for adherens junctions and possibly regulates the expression of claudin-4 (CLDN4) in tight junctions.
Studies indicate claudin 1 (CLDN-1 (Montrer CLDN1 Anticorps)) as a target for improving epidermal drug absorption and preventing HCV infection and of claudin 4 (CLDN-4) as a target for anticancer therapeutics.
Mislocalization claudin-3 (Montrer CLDN3 Anticorps) to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. The potential reasons for the paradoxical expression are discussed and a review of the literature, related all the alleged mechanisms of this mislocalization is provided.
Reg (Montrer KCNH2 Anticorps) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
a Grhl2 (Montrer GRHL2 Anticorps)/Ovol2 (Montrer OVOL2 Anticorps) network controls Cldn4 and Rab25 (Montrer RAB25 Anticorps) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
Data show that claudin-4 and claudin-7 (Montrer CLDN7 Anticorps) were observed in hepatocytes of severely damaged mouse and human livers.
The claudin-4-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1 (Montrer PRSS8 Anticorps)).
Claudin 4 has little effect on normal lung physiology but may function to protect against acute lung injury in mice.
The results suggest that progressive hydronephrosis in Cldn4(-/-) mice arises from urinary tract obstruction due to urothelial hyperplasia, and that Cld4 plays an important role in maintaining the homeostatic integrity of normal urothelium.
the results indicate that Grhl2 (Montrer GRHL2 Anticorps) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (Montrer CLDN3 Anticorps) and Cldn4, as well as of Rab25 (Montrer RAB25 Anticorps), which increases the Cldn4 protein and its localization at TJs
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3 (Montrer CLDN3 Anticorps)/-4 protein suggests structural modifications of the toxin to target specific claudins
Claudin-3 (Montrer CLDN3 Anticorps) in the apical-most regions maintains the impermeable tight junctions during lactation, and claudin-4 contributes
Claudin-4 overexpression is associated with epigenetic derepression in gastric carcinoma.
Tumor necrosis factor-alpha (Montrer TNF Anticorps) increases claudin-1 (Montrer CLDN1 Anticorps), 4, and 7 expression in renal tubular cells, altering permeability and transepithelial electrical resistance.
Claudin-4 expression shows age-dependent change in cellular localization on pig jejunal villous epithelial cells
These findings indicate that claudin-4 and -7 may play a role in the gingiva junctional epithelium even in the absence of tight junctions.
This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
, Clostridium perfringens enterotoxin receptor 1
, Williams-Beuren syndrome chromosomal region 8 protein
, clostridium perfringens enterotoxin receptor
, tight junction-associated protein
, claudin 4