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anti-Human IFNG Anticorps:
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Mouse (Murine) Polyclonal IFNG Primary Antibody pour IF (p), IHC (p) - ABIN669126
Huang, Li, Lin, Shi, Lin, Li, Xu: Upregulation of thyroid transcription factor-1 and human leukocyte antigen class I in Hashimoto's disease providing a clinical evidence for possible triggering autoimmune reaction. dans European journal of endocrinology / European Federation of Endocrine Societies 2011
Show all 18 Pubmed References
Human Monoclonal IFNG Primary Antibody pour FACS - ABIN1383935
Palmer, van Seventer: Human T helper cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals. dans Journal of immunology (Baltimore, Md. : 1950) 1997
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Mouse (Murine) Monoclonal IFNG Primary Antibody pour CyTOF, FACS - ABIN4900780
Deepak, Kumar, Kishore, Acharya: IL-13 from Th2-type cells suppresses induction of antigen-specific Th1 immunity in a T-cell lymphoma. dans International immunology 2009
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Human Monoclonal IFNG Primary Antibody pour FACS - ABIN4896668
Glässner, Eisenhardt, Krämer, Körner, Coenen, Sauerbruch, Spengler, Nattermann: NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner. dans Laboratory investigation; a journal of technical methods and pathology 2012
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Mouse (Murine) Monoclonal IFNG Primary Antibody pour ICS, Neut - ABIN1176984
Vikingsson, Pederson, Muller: Enumeration of IFN-gamma producing lymphocytes by flow cytometry and correlation with quantitative measurement of IFN-gamma. dans Journal of immunological methods 1994
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Human Monoclonal IFNG Primary Antibody pour Func, IP - ABIN1690730
Kofler, Chmielewski, Rappl, Hombach, Riet, Schmidt, Hombach, Wendtner, Abken: CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory t cells which can be overcome by preventing Lck activation. dans Molecular therapy : the journal of the American Society of Gene Therapy 2011
Show all 7 Pubmed References
Human Monoclonal IFNG Primary Antibody pour FACS - ABIN1383936
North, Webster, Farrant: Primary defect in CD8+ lymphocytes in the antibody deficiency disease (common variable immunodeficiency): abnormalities in intracellular production of interferon-gamma (IFN-gamma) in CD28+ ('cytotoxic') and CD28- ('suppressor') CD8+ subsets. dans Clinical and experimental immunology 1998
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Human Monoclonal IFNG Primary Antibody pour Func, IP - ABIN1690732
Veltkamp, Van Moorsel, Rijkers, Ruven, Van Den Bosch, Grutters: Toll-like receptor (TLR)-9 genetics and function in sarcoidosis. dans Clinical and experimental immunology 2010
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Human Polyclonal IFNG Primary Antibody pour ELISA, IHC (p) - ABIN3042815
Liu, Tan, Hu, Wu, Wang, Tang: Somatostatin inhibits the production of interferon-γ by intestinal epithelial cells during intestinal ischemia-reperfusion in macaques. dans Digestive diseases and sciences 2014
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Rat (Rattus) Polyclonal IFNG Primary Antibody pour ELISA, WB - ABIN3042510
Yan, Wang, Liang, Fu, Guo: HPV16L1-attenuated Shigella recombinant vaccine induced strong vaginal and systemic immune responses in guinea pig model. dans Human vaccines & immunotherapeutics 2015
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Allele G and genotype GG of IFNG rs2069705 were associated to risk for rheumatoid arthritis.
study suggested that miRNA-29b/142-5p overexpression and targeted inhibition of DNMTs expression resulted in decreased overall gene methylation and overexpression of the methylation-sensitive IFN-gamma gene.
The IFNg(+) mRNA signature may assist in identifying patients with improved outcomes with durvalumab, independent of PD-L1 assessed by IHC.
Increased sensitivity of Treg cells from patients with primary billiary cholangitis to low dose IL-12 drives their differentiation into IFNG secreting cells.
the beneficial effects of DP2 blockade or DP1 agonism were associated with increased interferon-lambda (IFN-lambda) [interleukin-28A/B (IL-28A/B)] expression and were lost upon IL-28A neutralization.
these two cytokine polymorphisms may play a role in predisposition to coronary heart disease.
We found IFN-gamma gene (rs2069705 and rs2430561), and 2 variants in lncRNA BANCR (rs6559446 and rs79823312) could increase coronary artery disease (CAD) susceptibility in allelic and dominant model, while IFN-gamma rs2069705 and rs2430561, BANCR rs79823312 were also associated with CAD risk in additive model. IFN-gamma rs2069705 and rs2430561 were associated with higher level of serum IFN-gamma in CAD patients
Our data suggest a nonredundant role of CD40L-CD40 interaction in neutrophil development and function that could be improved in vitro by rhIFN-gamma, indicating a potential novel therapeutic application for this cytokine.
We provide the first ex vivo characterization of human intestinal type 1 regulatory T cells. Selective downregulation of IL-10 by IFN-gamma(+) TR1 cells in response to proinflammatory cytokines is likely to drive excessive intestinal inflammation in patients with inflammatory bowel diseases.
human IL-12 and IL-23 are both required for optimal IFN-gamma-dependent immunity to mycobacteria, both individually and much more so cooperatively
homozygosity for the catalytically inactive P1104A missense variant of TYK2 selectively disrupts the induction of IFN-gamma by IL-23 and is a common monogenic etiology of tuberculosis
This review elaborated the relationship between IFN-gamma and IL-17 in the progress of periodontitis, providing new explanations into the development of periodontitis and alveolar bone destruction caused by the host immune response [review]
These results suggest that TET1 depletion inhibited Porphyromonas gingivalis lipopolysaccharide/IFN-gamma-induced M1 macrophage polarization through the NF-kappa B pathway in THP-1 cells.
We show that the glycans restrict the C-termini wagging motion into the solvent, limit their flexibility and keep them closer to the alpha-helical globule of hIFNg, thus possibly protecting them from proteolytic processing
there is a surprisingly robust proinflammatory interaction between the human stress response hormone cortisol and the immune activating cytokine IFN-upsilon
Interferon-gamma serum levels were high in patients with rapidly progressive interstitial lung disease and dermatomyositis.
Type 2 diabetes mellitus patients with diabetic kidney disease showed higher IL-6, IL-10, IFN-gamma and TNF-alpha levels than those without DKD.
A lower level of oncomir miRNA-21 and a higher level of immune modelling cytokine IFN-gamma detected in smokers could be a protective immune response to cigarette smoke. The higher level of IFN-gamma in smokers with a specific SNP genotype also suggests that a genetic interaction with smoking might predict the pathobiology of smoking related disease.
Serum levels of IL-10 and IFNgamma increased significantly in the group of allergic asthmatic patients with vitamin D supplementation, while IL-5, IL-9, and IL-13 decreased significantly.
IFN-gamma in peripheral hematopoietic stem cells/leukapheresis product seems to be an important biomarker of loss of response in multiple myeloma, suggesting a role in early post-transplant therapeutic management.
Tim-3(+) Treg are functionally and phenotypically distinct in head and neck squamous cell carcinoma (HNSCC) tumor-infiltrating lymphocytes (TIL), and are highly effective at inhibiting T-cell proliferation despite high PD-1 expression. IFN-gamma induced by anti-PD-1 immunotherapy may be beneficial by reversing Tim-3(+) Treg suppression
These findings identify an IFNgamma-macrophage pathway as a mechanistic link between obesity/insulin resistance and accelerated atherogenesis.
These data suggest IFNg is up-regulated by pFUS and after i.v.-infused Mesenchymal stromal cell (MSC) home to pFUS-treated kidneys, IFNg stimulates additional IL-10 production by MSC to improve acute kidney injury (AKI).
The IFN-gamma/Stat5 axis may be protective against persistent pressure overload-induced cardiac hypertrophy by activating the PI3K/Akt pathway.
IFN-gamma-producing CD4(+) but not CD8(+) T cells from immunized donor mice were sufficient for eliminating Chlamydia from the small intestine but not the large intestine of recipient mice.
Study shows that suppressing interferon-gamma stimulates microglial responses and repair of microbleeds in the diabetic brain.
neonatal cytotoxic t lymphocytes significantly reduce IFN-gamma production upon CD31 signaling.
IFNgamma-regulated molecules, but not MHC class II or antigen presentation by IECs is required for the early migration of antigen-specific CD4(+) T cells into the pancreatic islets.
IFNgamma-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin.
Canonical Ifn-gamma signaling via Ifngr1 and Stat1 is required for Parkinsonian neurodegenerative pathology
The findings of the present study indicated that soluble RAGE protected the heart from ischemia/reperfusion injuries, which might be mediated by promoting infiltration and the differentiation of macrophages into M1, which would then synthesize and secrete IFNgamma through activating the NFkappaappa B signaling pathway.
Our data suggest a novel mechanism for sRAGE in preventing myocardial ischemia/reperfusion (MI/R)-induced apoptosis in heart: sRAGE inhibits MI/R-induced apoptosis in cardiomyocytes by degrading p53 by beta5i subunit that is increased via upregulation of IFN-gamma.
This study unravels a new role for glucose metabolism in the differentiation process of Th1 cells, providing a mechanistic explanation for the importance of glycolysis in immune cell functions.
results therefore indicate that IFN-gamma production by NK cells plays an important role in activating and enhancing innate and adaptive immune responses at early stages of pulmonary pulmonary nontuberculous mycobacteria infections.
these results demonstrated that an increased TLR4 expression in CD38(-/-) mice could contribute to the aggravation of acute kidney injury through boosting of the production of IFN-gamma
Using high-throughput sequencing, we investigated the clonal diversity of the T cell receptors (TCRs) of infiltrating IFN-gamma and IL-17A-producing T cells in male and female SjS-susceptible (SjS(s)) C57BL/6.NOD-Aec1Aec2 mice. There were elevated frequencies of IFN-gamma and IL-17A-producing effector T cell populations in female SjS(S) mice compared to male SjS(S) mice.
Results suggest that altered interferon gamma (IFN-gamma) levels could be used as peripheral biomarker of cognitive deficit and treatment response.
vitamin D suppresses lipopolysaccharide-induced HIF-1alpha to block IFNgamma and IL-1beta productions.
These results suggest that IFN-gamma in the lesional skin may reduce ceramides with long-chain fatty acids by decreasing the expression of fatty acid elongases. IFN-gamma may contribute to the chronicity of atopic dermatitis by impairing barrier function.
IFN-gamma plays a crucial role in curtailing enteric coronavirus infection and may serve as an effective prophylactic and/or therapeutic agent against transmissible gastroenteritis virus infection.
The regulatory effect of IFN-gamma on CYP3A29 expression is mediated via PXR.
Mapping of QTL for mycoplasma and tetanus antibodies and IFNgamma.
Data show taht the expression of PoIFN-gamma in insect cells was confirmed by Western Blot, indirect immunofluorescence assay and indirect ELISA.
IFNgamma production from the frozen peripheral blood mononuclear cells was significantly higher than that from the fresh ones.
Translational control of IL-18 expression by its 5'-UTR limits production of IL-18, resulting in restricted expression of mRNA and protein IFN-gamma in this model of crescentic glomerulonephritis(GN). Might amplify CD8+-mediated macrophage-dependent GN.
selective changes in immature crypt cells induced by IFN-gamma bound to extracellular matrix could contribute to inappropriate responsiveness to commensal bacteria in inflammatory bowel diseases
A functional single nucleotide polymorphism is reported in the coding region of IFN-gamma cDNA that markedly reduces antiviral activity of the IFN-gamma protein.
The expression of IFN-gamma in recombiannt Lactococcus lactis as a tool for investigating downregulation of allergic predisposition of pigs to experimental food allergy is reported.
CD3(-) CD8(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma, and that IL-15 elicits IFN-gamma production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 antigen, IFN-gamma]
Increase of cells expressing PD-1 and PD-L1 and enhancement of IFN-gamma production via PD-1/PD-L1 blockade in bovine mycoplasmosis.
The expression of multiple toll-like receptors, interferon-gamma, and interleukin-12 (IL-12) in cattle with low and high proviral loads of bovine leukemia virus are reported.
Diet-driven interferon-gamma enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy.
Data suggest that luteolytic factors (such as IFNG, tumor necrosis factor alpha, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These findings indicate that IFN-gamma production correlates negatively and the production of antibodies against N. caninum is uncorrelated with plasma pregnancy-associated glycoproteins levels.
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 production before calving.
Genetic characterization of IFNG gene was done in resistant and susceptible animals of Sahiwal cattle (n = 95) and Friesian (n = 92).
Data suggest that activation of gammadelta T cells to IFN-gamma production, NK cell-like killing plays a pivotal role in controlling virus infection.
The differential expression levels of IFN-gamma mRNA between cattle and buffalo could be due to a conserved 4 base (GTCT) deletion in the promoter region of buffalo.
SNPs in IFNG, IFNGR1 and R2, IL22, and IL22RA1 were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.
Nuclear localization sequence of bovine gamma-interferon provides translocation of recombinant protein to yeast Pichia pastoris cell nucleus
The upregulation of TNFRI mRNA expression by IFNG suggests that TNF and IFNG synergistically affect the death of luteal endothelial cells resulting in acute luteolysis
Data demonstrated that the monoclonal antibodies secreted by the four hybridoma cell lines could react specifically to the recombinant BovIFN-gamma.
The entire bovine IFN-gamma gene (BoIFNG) and 2605 bp of its promoter DNA were sequenced. A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae.
Bovine interferon gamma demonstrates no effect on P-glycoprotein transport activity in human Caco-2 intestinal epithelial cells with rhodamine 123 as susbstrate.
In giant cell arteritis, IFN-gamma functional polymorphisms are associated with clinical manifestations of severity rather than susceptibility to this vasculitis.
The majority of patients with gad-enhancing lesions showed PLP/IFN gamma and MBP/IFN gamma recurrent burst responses
A polymorphism within the interferon gamma gene is a risk factor in severe acute respiratory syndrome susceptibility.
Intradermal sensitization of cows in the subclinical stage of M. paratuberculosis infection will upregulate expression of interferon gamma, enhancing the sensitivity of this assay.
This study compared the protective immune responses to bovine tuberculosis induced in cattle vaccinated with BCG Danish with those induced by BCG Pasteur.
These results indicate that in equine corpus luteum, cytokines TNF, IFNG and FASL regulate nitric oxide activity, via eNOS expression modulation.
IFN-gamma expression in foals appears to be controlled by DNA methylation in the promoter region of Ifng. The age-associated demethylation of the DNA in foals may be induced by exposure to environmental antigens and their effect on lymphoproliferation.
These data show the presence of cytokines TNF and IFNG, and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.
IFNgamma expression in colonic epithelial cells was regulated by TGFB1.
Higher KIR2DL4 copy numbers is associated with an increased IFN-gamma production in NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Data show that viral set-point in simian immunodeficiency virus diseasewas is associated with expression of interferon gamma -stimulated genes.
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine interferon-gamma.
The zfIFN-gamma monoclonal antibody specifically recognises E. coli produced recombinant IFN-gamma protein and zfIFN-gamma produced in transfected HEK293 cells, by Western blot analysis. IFN-gamma protein is produced as a dimer, and a good correlation exists between transcript expression levels and protein levels.
There are two IFN-gamma-like genes are present in tandem, 7.0 kb apart from each other, in the zebrafish genome.
IFN-gamma signaling acts cell autonomously to control the endothelial-to-hematopoietic stem cell transition
These results support a central role of IFNgamma in mediating biliary defects in developing vertebrates, and further support a role for IFNgamma in the pathogenesis of disorders such as biliary atresia.
These data throw light on partially redundant functions of fish IFNgamma genes.
Conditions are identified in which Ifn-gamma1 and Ifn-gamma2 are induced in fish larvae and adults; the receptor complex for Ifn-gamma2 includes cytokine receptor family B (Crfb)6 together with Crfb13 and Crfb17.
zebrafish IFN-gamma1 and IFN-gamma2 are functionally equivalent to mammalian IFN-gamma
Evidence is provided for a pivotal role of group II interferon of zebrafish in the early stages of viral infections, whereas group I interferons exert a slow but more powerful induction of several antiviral and proinflammatory genes.
the identification of a novel isoform of the zebrafish (Danio rerio) IFNGR1 is reported.
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.
, immune interferon
, interferon gamma
, gamma interferon
, IFN gamma
, interferon gamma type 2
, interferon, gamma
, Interferon gamma
, interferon alpha