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Human Monoclonal IRF1 Primary Antibody pour ELISA, WB - ABIN561520
Baumjohann, Okada, Ansel: Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. dans Journal of immunology (Baltimore, Md. : 1950) 2011
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Following spring viremia of carp (Montrer ANKRD1 Anticorps) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (Montrer ANKRD1 Anticorps) virus. data provide evidence that fish and mammals have evolved a similar IRF (Montrer TRIM63 Anticorps)-dependent regulatory mechanism fine-tuning IFN gene activation.
our results indicated that IL-1beta (Montrer IL1B Anticorps) treatment resulted in a significant increase in expression of the transcriptional factor interferon regulatory factor-1 (IRF-1) at both the mRNA and protein levels, which was significantly ameliorated by treatment with Nebivolol. The combination of these findings suggests that Nebivolol can potentially be applied in human osteoarthritis treatment
The authors observe that IRF1 expression is mediated by ZEB1 (Montrer ZEB1 Anticorps) de-repression, and the study demonstrates how airway remodelling/fibrosis is associated with a defective mucosal antiviral response through ZEB1 (Montrer ZEB1 Anticorps)-initiated epigenetic silencing in respiratory virus infection.
These unprecedented data suggest that IRF1 and NF-kappaB (Montrer NFKB1 Anticorps) orchestrate the TLR4 (Montrer TLR4 Anticorps)-primed immunomodulatory response of hMSCs and that this response also involves the PI3K (Montrer PIK3CA Anticorps) pathway.
Zinc is capable of ameliorating the allogeneic immune reaction by enhancement of antigen-specific iTreg cells due to modulation of essential molecular targets by upregulation of Foxp3 (Montrer FOXP3 Anticorps) and KLF-10 (Montrer KLF10 Anticorps) and downregulation of IRF-1.
As a measure of PD-L1 (Montrer CD274 Anticorps) expression capability, IRF-1 expression may be a more valuable predictive biomarker for anti-PD-1 (Montrer PDCD1 Anticorps) therapy than PD-L1 (Montrer CD274 Anticorps) itself.
Upregulation of IRF1 in human adipocytes leads to phenotypes associated with obesity-related inflammation.
Regulation of transcriptional activators by DNA-binding domain (DBD) ubiquitination has shown that, when attached to the DBD of either p53 or IRF-1, ubiquitin is orientated towards, and makes contact with, the DNA.
In SK-Hep1 cells, an increase in apoptosis and decrease in autophagy were observed after IFN-gamma (Montrer IFNG Anticorps) stimulation, which was accompanied with increasing IRF-1 levels.
HNP1 (Montrer DEFA1 Anticorps) upregulation of cytokine expression in pDCs was inhibited by blockade of NF-kappaB (Montrer NFKB1 Anticorps) activation or knockdown of IRF1, demonstrating the importance of these two signaling events in HNP1 (Montrer DEFA1 Anticorps)-induced pDC (Montrer PNKD Anticorps) activation.
Data show that the Japanese encephalitis virus (JEV)-induced expression of miR (Montrer MLXIP Anticorps)-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5 (Montrer SOCS5 Anticorps)).
Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses.
In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression.
The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig.
IRF-1 may be a critical factor in augmenting LPS (Montrer TLR4 Anticorps)-induced oxidative stress and mitochondrial damage in macrophages.
IRF-1 plays a key role in controlling caspase-1 (Montrer CASP1 Anticorps)-dependent pyroptosis and inflammation.
Results indicate IRF-1 is one of the key transcriptional factors for the prevention of neointimal formation involving angiotensin II type 2 receptors.
Data show that HCFC2 (Montrer HCFC2 Anticorps) is a critical component of the IRF1 and IRF2 (Montrer IRF2 Anticorps) transcriptional machinery that regulates Tlr3 (Montrer TLR3 Anticorps) gene expression.
Our studies uncovered the critical role of two transcription factors, IRF1 and BATF, in preparing the chromatin landscape for induction of the Tr1 (Montrer TXNRD1 Anticorps) gene network in response to IL-27 (Montrer IL27 Anticorps) signaling, where BATF acted as a pioneer factor and prepared the genomic landscape for the binding of additional transcription factors that define the Tr1 (Montrer TXNRD1 Anticorps) lineage.
IRF-1 and interferon-alpha (Montrer IFNA Anticorps) with interferon-beta (Montrer IFNB1 Anticorps) cooperate to control acute gammaherpesvirus infection.
this study shows that binding motifs for the transcription factors STAT1 (Montrer STAT1 Anticorps) and IRF1 are associated with robust and IL-4 (Montrer IL4 Anticorps)-resistant responses to IFN-gamma (Montrer IFNG Anticorps) in macrophages
5AZ had a protective effect after MI by potentiation of IRF1 sumoylation and is suggested as a novel therapeutic intervention for cardiac repair.
direct the expression of a set of genes, the IRF8 (Montrer IRF8 Anticorps)/IRF1 regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
interferon regulatory factor 1
, interferon regulatory factor 11
, interferon responsive factor 1