TRKA Kit ELISA

N° du produit ABIN2042710

Détail du produit TRKA Kit ELISA

Antigène: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Gamme de detection: 6-10000 pg/mL

Seuil minimal de détection: 6 pg/mL

Application: ELISA

Marque: BioAssay™

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Sensibilité: < 10 pg/mL

Ingrédients: 96-well plate pre-coated with anti-TrkA, Human
Lyophilized recombinant TrkA, Human standard, 10 ng/tube, 2Ea
Avidin-Biotin-Peroxidase Complex (ABC), 130 µL (1:100 dilution)
Sample diluent buffer, 30 mL
Antibody diluent buffer, 10 mL
ABC diluent buffer, 10 mL
TMB color developing agent, 10 mL
TMB stop solution, 10 mL

Information d'application

Plaque: Pre-coated

Protocole: Sandwich ELISA quantitative detection kit for Human trkA in cell culture supernates, cell lysates and tissue homogenates.Tropomyosin receptor kinase A (TrkA) are efficacious in attenuating skeletal pain.1 TrkA mutants were able to activate signaling cascades and were even more efficient in promoting neurite outgrowth than the wild-type receptor.2 TrkA is part of a sub-family of protein kinases which includes TrkB and TrkC. Also, there are other neurotrophic factors structurally related to NGF BDNF (for Brain-Derived Neurotrophic Factor), NT-3 (for Neurotrophin-3) and NT-4 (for Neurotrophin-4). While TrkA mediates the effects of NGF, TrkB is bound and activated by BDNF, NT-4, and NT-3. Further, TrkC binds and is activated by NT-3.3 TrkA receptor was found in kehumanoconus-affected corneas, along with an increased level of repressor isoform of Sp3 transcription factor.4 The standard product used in this kit is extracellular part (A33-P418) of recombinant human TRKA, consisting of 386 amino acids with the molecular weight of 69kD.

Restrictions: For Research Use only

Stockage

Stock: 4 °C/-20 °C

Détail du antigène

Antigène: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Autre désignation: TrkA (NTRK1 Produits)

Synonymes: MTC Kit ELISA, TRK Kit ELISA, TRK1 Kit ELISA, TRKA Kit ELISA, Trk-A Kit ELISA, p140-TrkA Kit ELISA, CDHF12 Kit ELISA, CDHR16 Kit ELISA, HSCR1 Kit ELISA, MEN2A Kit ELISA, MEN2B Kit ELISA, MTC1 Kit ELISA, PTC Kit ELISA, RET-ELE1 Kit ELISA, RET51 Kit ELISA, Trk Kit ELISA, C80751 Kit ELISA, Tkr Kit ELISA, TrkA Kit ELISA, trk Kit ELISA, trka Kit ELISA, CTRKA Kit ELISA, trkA Kit ELISA, neurotrophic receptor tyrosine kinase 1 Kit ELISA, ret proto-oncogene Kit ELISA, neurotrophic tyrosine kinase, receptor, type 1 Kit ELISA, NTRK1 Kit ELISA, RET Kit ELISA, Ntrk1 Kit ELISA, ntrk1 Kit ELISA

ID gène: 4914

UniProt: P04629

Pathways: Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process