NLRP3 Produits
(NLR Family, Pyrin Domain Containing 3 (NLRP3))
Catégories
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008].
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Catégories NLRP3 en vedette
NLRP3 Anticorps
High quality antibodies with extensive validation data.
NLRP3 Kits ELISA
Reliable ELISA kits for a wide range of species.
NLRP3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
NLRP3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Application
WB, IHC, IF, IP
Validations
- (60)
- (5)
N° du produit
ABIN1169100
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Dog, Human, Mouse, Rat
Application
WB, ELISA, IHC (p), FACS, IF (p), ICC, IF (cc), IHC (fro)
Validations
- (11)
- (15)
N° du produit
ABIN1386361
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (8)
N° du produit
ABIN7443710
Quantité
100 μL
Fiche technique
Fiche technique
NLRP3 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6971279
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6958211
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6958210
Quantité
96 tests
Fiche technique
Fiche technique
NLRP3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (5)
- (1)
N° du produit
ABIN1312675
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124184
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1312677
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits NLRP3
: "Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by NLRP3 Activation." dans: Microbiology spectrum, Vol. 9, Issue 2, pp. e0073021, (2022) (PubMed).: "XIST Inhibition Attenuates Calcium Oxalate Nephrocalcinosis-Induced Renal Inflammation and Oxidative Injury via the miR-223/NLRP3 Pathway." dans: Oxidative medicine and cellular longevity, Vol. 2021, pp. 1676152, (2022) (PubMed).
: "Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway." dans: Nutrients, Vol. 12, Issue 5, (2021) (PubMed).
: "P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages." dans: Cell death & disease, Vol. 11, Issue 5, pp. 394, (2021) (PubMed).
: "Enhanced Autolysosomal Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer's Disease." dans: Frontiers in aging neuroscience, Vol. 13, pp. 629891, (2021) (PubMed).
: "Roseburia intestinalis‑derived flagellin ameliorates colitis by targeting miR‑223‑3p‑mediated activation of NLRP3 inflammasome and pyroptosis." dans: Molecular medicine reports, Vol. 22, Issue 4, pp. 2695-2704, (2021) (PubMed).
: "NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis." dans: Nature communications, Vol. 10, Issue 1, pp. 4375, (2020) (PubMed).
: "LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression." dans: Bioscience reports, Vol. 40, Issue 8, (2020) (PubMed).
: "25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner." dans: Journal of neuroinflammation, Vol. 17, Issue 1, pp. 192, (2020) (PubMed).
: "Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture." dans: Immunology, Vol. 161, Issue 1, pp. 39-52, (2020) (PubMed).
Synonymes et noms alternatifs relatifs à NLRP3
NLR family pyrin domain containing-like (NLRPL), NLR family pyrin domain containing 3 (NLRP3), NLR family, pyrin domain containing 3 L homeolog (nlrp3.L), NLR family, pyrin domain containing 3 (Nlrp3), agtavprl, AGTAVPRL, AII, AII/AVP, avp, AVP, C1orf7, CIAS1, cias1, Cias1, CLR1.1, FCAS, FCU, Mmig1, MWS, Nalp3, nalp3, NALP3, pypaf1, PYPAF1, Pypaf1Protein level used designations for NLRP3
- NACHT, LRR and PYD domains-containing protein 3
- cold autoinflammatory syndrome 1
- cryopyrin
- NLR family, pyrin domain containing 3
- NACHT, LRR and PYD domains-containing protein 3-like
- NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
- NACHT, LRR and PYD containing protein 3
- PYRIN-containing APAF1-like protein 1
- caterpiller protein 1.1
- cold autoinflammatory syndrome 1 protein
- nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
- NACHT/LRR/pyrin domain-containing protein 3
- cold autoinflammatory syndrome 1 homolog
- cold autoinflammatory syndrome 1 protein homolog
- mast cell maturation inducible protein 1
- mast cell maturation-associated-inducible protein 1
- NLR family pyrin domain containing 3
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