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anti-Human RORC Anticorps:
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Human Polyclonal RORC Primary Antibody pour ELISA, IHC (p) - ABIN271147
Tosolini, Kirilovsky, Mlecnik, Fredriksen, Mauger, Bindea, Berger, Bruneval, Fridman, Pagès, Galon: Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. dans Cancer research 2011
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Human Monoclonal RORC Primary Antibody pour FACS - ABIN4895230
Verma, Dempsey, Long, Davies, Barry, Fallon, Volkov, Kelleher: Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling. dans The Journal of biological chemistry 2012
Human Monoclonal RORC Primary Antibody pour FACS - ABIN4895234
Zielinski, Mele, Aschenbrenner, Jarrossay, Ronchi, Gattorno, Monticelli, Lanzavecchia, Sallusto: Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β. dans Nature 2012
Human Monoclonal RORC Primary Antibody pour FACS - ABIN4895237
Wongkajornsilp, Wamanuttajinda, Kasetsinsombat, Duangsa-ard, Sa-ngiamsuntorn, Hongeng, Maneechotesuwan: Sunitinib indirectly enhanced anti-tumor cytotoxicity of cytokine-induced killer cells and CD3⁺CD56⁺ subset through the co-culturing dendritic cells. dans PLoS ONE 2013
Cow (Bovine) Polyclonal RORC Primary Antibody pour IHC, WB - ABIN2782284
Huang, Xie, Wang, Sun: Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity. dans Expert opinion on therapeutic targets 2007
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Cow (Bovine) Polyclonal RORC Primary Antibody pour WB - ABIN2777822
Huang, Huang, Lee, Ng, Chang: Postirradiation sinus mucosa disease in nasopharyngeal carcinoma patients. dans The Laryngoscope 2007
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Herein, molecular dynamics simulations were conducted on HC9-ROR-gamma and XY018-ROR-gamma complexes to understand their conformational features at molecular level and the influence of XY018 binding on the dynamics of ROR-gamma with the aid of post-dynamic analytical tools.
RORgammat mRNA expression levels were significantly different among groups of Hepatitis B virus infection patients with different disease severities.
siRNA-mediated knockdown of T-bet and RORgammaT contributes to decreased inflammation in preeclampsia.
human melanoma development and aggressiveness is associated with decreased expression of RORalpha and RORgamma, suggesting that RORs could be important in melanoma progression and host responses against the tumor
There was no significant difference in FOXP3, RORgammat, IL-10 protein expression and supernatant PBMCs IL-10 in chronic heart failure patients as compared to control.
TNF-alpha inhibitors decrease histone (H)3 and H4 acetylation in the RORgammat gene promotor region by decreasing the recruitment of the acetyltransferases p300, CBP and PCAF in Th17 cells, from rheumatoid arthritis patients.
Here we attempt a comprehensive review of the post-translational regulation of RORgammat, an area that holds the potential to transform the way we target the RORgammat/IL-17 pathway
CYP11A1- derived hydroxyvitamin D derivatives as "inverse" agonists on ROR-alpha and ROR-gamma.
RORgamma mediates epithelial-mesenchymal transition of hepatocytes during hepatic fibrosis facilitated by TGFbeta1.
The interaction between c-Maf and RORgammat, and Blimp-1.
RORgammat and RORalpha have overlapping roles in human Th17 cell differentiation through regulation of a defined common set of Th17 genes
this review on RORC as a transcription factor required for the generation of type 3 lymphoid cells, which induce the development of lymphoid tissues, provide resistance of epithelial stem cells to injury, maintain homeostasis with the symbiotic microbiota, orchestrate defense against extracellular microbes, and regulate allergic responses
IKKalpha-dependent phosphorylation of S376 stimulated whereas IKKalpha-independent phosphorylation of S484 inhibited RORgammat function in Th17 differentiation.
There are 2 putative binding motifs for specificity protein transcription factors from the specificity protein/Kruppel-like factor family in the promoter of human RORgammaT. SP2 recognized binding motifs in the human RORgammaT promoter, which was critical for maintaining expression.
this study shows that all human innate lymphoid cells can be generated through an RORgammat+ developmental pathway from a common progenitor in secondary lymphoid tissues
ROR-gamma is overexpressed and amplified in metastatic castration resistant prostate tumors, and ROR-gamma drives androgen receptor (AR) expression in the tumors. ROR-gamma recruits nuclear receptor coactivator 1 and 3 (NCOA1 and NCOA3, also known as SRC-1 and SRC-3) to an AR-ROR response element (RORE) to stimulate AR gene transcription.
Data suggest that apo RORC adopts active conformation capable of recruiting coactivator peptides that stabilize helix 12 of the active state in the absence of a ligand; ligand-bound RORC binds inverse agonists that disrupt critical interactions that stabilize helix 12; helix 12 destabilization in the active state shifts the conformational equilibrium of RORC toward an inactive state.
There is selective migration or survival of RORgammat-positive cells in Secondary Progressive Multiple Sclerosis patient meninges.
Retinoid-related orphan receptor gammat may be associated with NK22 cells in reproduction. Particularly, higher expression of retinoid-related orphan receptor gammat may be associated with elevated NK22 cells in unexplained recurrent pregnancy loss.
Study reports on the role of RORgamma in the regulation of genetic programs and pathways promoting breast carcinogenesis. It shows that RORgamma expression is associated with checkpoint control and DNA-repair genes and, its up-regulation is associated with the higher probability of metastasis-free survival.
The total frequencies for the combined genotypes for the bGH and RORC genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle
The role of the orphan receptor C allele variation on intramuscular fat in beef cattle is reported.
The RORC:g.3290T>G single nucleotide polymorphism had the strongest association with marbling.
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known\; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.
RAR-related orphan nuclear receptor variant 2
, nuclear receptor ROR-gamma
, nuclear receptor RZR-gamma
, nuclear receptor subfamily 1 group F member 3
, retinoic acid-binding receptor gamma
, retinoid-related orphan receptor gamma
, RAR-related orphan receptor gamma
, retinoid-related orphan receptor-gamma
, thymus orphan receptor