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RORgammat(+) iNKT and gammadelta-hi T cells show IL-23 mediated Th17-like immune responses and were clearly enriched within inflamed joints of spondyloarthritis patients where they act as major IL-17 secretors.
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Herein, molecular dynamics simulations were conducted on HC9-ROR-gamma and XY018-ROR-gamma complexes to understand their conformational features at molecular level and the influence of XY018 binding on the dynamics of ROR-gamma with the aid of post-dynamic analytical tools.
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RORgammat mRNA expression levels were significantly different among groups of Hepatitis B virus infection patients with different disease severities.
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siRNA-mediated knockdown of T-bet and RORgammaT contributes to decreased inflammation in preeclampsia.
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human melanoma development and aggressiveness is associated with decreased expression of RORalpha and RORgamma, suggesting that RORs could be important in melanoma progression and host responses against the tumor
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There was no significant difference in FOXP3, RORgammat, IL-10 protein expression and supernatant PBMCs IL-10 in chronic heart failure patients as compared to control.
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TNF-alpha inhibitors decrease histone (H)3 and H4 acetylation in the RORgammat gene promotor region by decreasing the recruitment of the acetyltransferases p300, CBP and PCAF in Th17 cells, from rheumatoid arthritis patients.
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Here we attempt a comprehensive review of the post-translational regulation of RORgammat, an area that holds the potential to transform the way we target the RORgammat/IL-17 pathway
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CYP11A1- derived hydroxyvitamin D derivatives as "inverse" agonists on ROR-alpha and ROR-gamma.
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RORgamma mediates epithelial-mesenchymal transition of hepatocytes during hepatic fibrosis facilitated by TGFbeta1.
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The interaction between c-Maf and RORgammat, and Blimp-1.
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RORgammat and RORalpha have overlapping roles in human Th17 cell differentiation through regulation of a defined common set of Th17 genes
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this review on RORC as a transcription factor required for the generation of type 3 lymphoid cells, which induce the development of lymphoid tissues, provide resistance of epithelial stem cells to injury, maintain homeostasis with the symbiotic microbiota, orchestrate defense against extracellular microbes, and regulate allergic responses
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IKKalpha-dependent phosphorylation of S376 stimulated whereas IKKalpha-independent phosphorylation of S484 inhibited RORgammat function in Th17 differentiation.
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There are 2 putative binding motifs for specificity protein transcription factors from the specificity protein/Kruppel-like factor family in the promoter of human RORgammaT. SP2 recognized binding motifs in the human RORgammaT promoter, which was critical for maintaining expression.
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this study shows that all human innate lymphoid cells can be generated through an RORgammat+ developmental pathway from a common progenitor in secondary lymphoid tissues
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ROR-gamma is overexpressed and amplified in metastatic castration resistant prostate tumors, and ROR-gamma drives androgen receptor (AR) expression in the tumors. ROR-gamma recruits nuclear receptor coactivator 1 and 3 (NCOA1 and NCOA3, also known as SRC-1 and SRC-3) to an AR-ROR response element (RORE) to stimulate AR gene transcription.
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Data suggest that apo RORC adopts active conformation capable of recruiting coactivator peptides that stabilize helix 12 of the active state in the absence of a ligand; ligand-bound RORC binds inverse agonists that disrupt critical interactions that stabilize helix 12; helix 12 destabilization in the active state shifts the conformational equilibrium of RORC toward an inactive state.
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There is selective migration or survival of RORgammat-positive cells in Secondary Progressive Multiple Sclerosis patient meninges.
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Retinoid-related orphan receptor gammat may be associated with NK22 cells in reproduction. Particularly, higher expression of retinoid-related orphan receptor gammat may be associated with elevated NK22 cells in unexplained recurrent pregnancy loss.
