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Human Polyclonal UBE2V2 Primary Antibody pour ELISA, WB - ABIN249511
Fritsche, Rehli, Krause, Andreesen, Kreutz: Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. dans Biochemical and biophysical research communications 1997
Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2) and ring finger protein 4 (RNF4 (Montrer RNF4 Anticorps)) together induce an active conformation of the ubiquitin-conjugating enzyme (Montrer Ube2t Anticorps) Ubc13 (Montrer UBE2N Anticorps)-ubiquitin (Ubc13 (Montrer UBE2N Anticorps)~Ub) thioester.
Functional analysis of selected regulated proteins revealed that knockdown of HNRPD (Montrer HNRNPD Anticorps), PHB2 (Montrer PHB2 Anticorps) and UB2V2 can increase HCMV replication, while knockdown of A4 and KSRP (Montrer KHSRP Anticorps) resulted in decreased HCMV replication.
Data show RING finger (Montrer PCGF1 Anticorps) (RNF (Montrer TRIM31 Anticorps)) E3 ubiquitin ligase (Montrer MUL1 Anticorps) RNF8 (Montrer RNF8 Anticorps) dimerizes and binds to E2 ubiquitin-conjugating complex Ubc13 (Montrer UBE2N Anticorps)/Mms2 with formation of Lys (Montrer LYZ Anticorps)-63 ubiquitin chains, whereas the RNF168 (Montrer RNF168 Anticorps) RING domain is a monomer and does not catalyze Lys (Montrer LYZ Anticorps)-6 ubiquitylation.
the crystal structure of human OTUB1 (Montrer OTUB1 Anticorps) in complex with human UBC13 (Montrer UBE2N Anticorps) and MMS2
entire coding region and splice junctions of RNF8 (Montrer RNF8 Anticorps), UBC13 (Montrer UBE2N Anticorps) and MMS2 genes were screened for mutations in affected index cases from 123 Northern Finnish breast cancer families
Ubc13 (Montrer UBE2N Anticorps)-Mms2 and Lys63-polyubiquitin (Montrer UBB Anticorps) chains are associated with signaling cellular stress
UBE2v2 signalling through PCNA (Montrer PCNA Anticorps) ubiquitination is not required for immunoglobulin diversification in DT40 cells.
The results in this study allowed identification of important residues of the Ubc13 (Montrer UBE2N Anticorps)-Mms2 interface, determine a correlation between heterodimer formation and function, and conclude why Mms2 forms a specific complex with Ubc13 (Montrer UBE2N Anticorps) but not other Ubc (Montrer RPS27A Anticorps) proteins.
Insight into the influence of protein dynamics on the affinity of ubiquitin for Mms2.
Data demonstrate that divergent activities of Ubc13 (Montrer UBE2N Anticorps) rely on its pairing with either of two Uevs, Uev1A (Montrer UBE2V1 Anticorps) or Mms2.
Ang II (Montrer AGT Anticorps) type 2 receptor signaling attenuates DNA damage and consequent vascular senescence at least in part through methyl methanesulfonate sensitive 2 (MMS2) transactivation.
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.
1 alpha,25-dihydroxyvitamin D3-inducible
, DDVit 1
, MMS2 homolog
, enterocyte differentiation promoting factor
, enterocyte differentiation-associated factor 1
, enterocyte differentiation-associated factor EDAF-1
, enterocyte differentiation-promoting factor 1
, methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of
, vitamin D3-inducible protein
, ubiquitin-conjugating enzyme E2v2
, ubiquitin-conjugating enzyme variant MMS2
, methyl methanesulfonate sensitive 2
, ubc-like protein MMS2
, ubiquitin-conjugating enzyme E2 variant 2
, Ubiquitin-conjugating enzyme E2 variant 2
, TMEM189-UBE2V1 readthrough transcript