Profil protéine

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Alternative names and synonyms associated with IKZF1

• IKAROS family zinc finger 1 (IKZF1) anticorps
• IKAROS family zinc finger 1 (Ikzf1) anticorps
• IKAROS family zinc finger 1 (Ikaros) (ikzf1) anticorps
• IKAROS family zinc finger 1 (ikzf1) anticorps

• 5832432G11Rik anticorps
• hik-1 anticorps
• hlk-1 anticorps
• hs.54452 anticorps
• ik1 anticorps
• Afficher tous les alias de synonymes
• Ikaros anticorps
• ikzf1 anticorps
• LyF-1 anticorps
• lyf1 anticorps
• MGC108252 anticorps
• mKIAA4227 anticorps
• pro0758 anticorps
• RGD1562979 anticorps
• Zfpn1a1 anticorps
• Znfn1a1 anticorps

Protein level used designations for IKZF1

CLL-associated antigen KW-6 , DNA-binding protein Ikaros , Ikaros (zinc finger protein) , ikaros family zinc finger protein 1 , lymphoid transcription factor LyF-1 , zinc finger protein, subfamily 1A, 1 (Ikaros) , Ikaros transcription factor , KAROS family zinc finger 1 (Ikaros) , IKAROS family zinc finger 1 (Ikaros) , DNA-binding protein Ikaros-like , zinc finger protein subfamily 1A, 1