NEIL2 Protein (His tag)

N° du produit ABIN1098272

Détail du produit

Antigène: NEIL2 (Endonuclease 8-like 2 (NEIL2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette NEIL2 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Purification: purified by chromatography

Pureté: > 85 % by SDS - PAGE

Information d'application

Commentaires:

Synonyms: Endonuclease 8-like 2, NEH2, NEI2, Nei-like protein 2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 1 MM DTT, 10% glycerol, 0.1 M NaCl

Stock: 4 °C

Stockage commentaire: Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: NEIL2 (Endonuclease 8-like 2 (NEIL2))

Autre désignation: NEIL2 (NEIL2 Produits)

Synonymes: NEH2 Protein, NEI2 Protein, Gm1212 Protein, nei like DNA glycosylase 2 Protein, nei like 2 (E. coli) Protein, NEIL2 Protein, Neil2 Protein

Sujet: Endonuclease 8-like 2, also known as NEIL2, belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction. It has negligible or undetectable activity with 8-oxoguanine, thymine glycol, 2-hydroxyadenine, hypoxanthine, and xanthine. Recombinant human NEIL2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 39.4 kDa (356aa), confirmed by MALDI-TOF

NCBI Accession: NP_659480

Pathways: Réparation de l'ADN