Netrin 1 Protein (NTN1) (AA 25-604) (Fc Tag)
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- Antigène Voir toutes Netrin 1 (NTN1) Protéines
- Netrin 1 (NTN1)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 25-604
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Origine
- Souris, Humain, Rat
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Netrin 1 protéine est marqué à la Fc Tag.
- Application
- SDS-PAGE (SDS)
- Specificité
- Binds to human, mouse and rat UNC5B.
- Réactivité croisée
- Humain, Souris, Rat (Rattus)
- Attributs du produit
- Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1.
- Pureté
- >95 % (SDS-PAGE)
- niveau d'endotoxine
- <0.1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product NTN1 Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Induces pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by inhibiting apoptosis mediated by the receptors DCC or UNC5B (at 150ng /ml). Induces axon outgrowth.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 100 μL sterile distilled water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS plus protein stabilizer. No BSA included. The protein stabilizer shows no interference with protein activity.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Date de péremption
- 6 months
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Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth." dans: The Journal of biological chemistry, Vol. 287, Issue 35, pp. 30014-23, (2012) (PubMed).
: "DCC constrains tumour progression via its dependence receptor activity." dans: Nature, Vol. 482, Issue 7386, pp. 534-7, (2012) (PubMed).
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Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth." dans: The Journal of biological chemistry, Vol. 287, Issue 35, pp. 30014-23, (2012) (PubMed).
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- Antigène
- Netrin 1 (NTN1)
- Autre désignation
- Netrin-1 (NTN1 Produits)
- Synonymes
- ntn1-A Protein, Netrin-1 Protein, NTN1 Protein, unc-6 Protein, MGC147073 Protein, NTN1L Protein, AI561871 Protein, BC019633 Protein, netrin-1 Protein, netrin 1 L homeolog Protein, netrin 1 Protein, ntn1.L Protein, NTN1 Protein, ntn1 Protein, Ntn1 Protein
- Sujet
- Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.
- Poids moléculaire
- ~90kDa (SDS-PAGE)
- UniProt
- O95631
- Pathways
- Regulation of Cell Size
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