Notch 2 (NOTCH2) (AA 26-494), (Extracellular Domain) protein (Fc Tag)

Détails pour le produit réf. ABIN1344244
Nom de la protéine
  • AGS2
  • HJCYS
  • hN2
  • AI853703
  • N2
  • notch6
  • sb:cb884
  • neurogenic locus notch homolog protein 2
  • notch 2
  • notch 3
  • LOC581186
  • NOTCH2
  • notch3
  • Notch2
  • notch2
Attributs du protein
Extracellular Domain, AA 26-494
2
1
1
1
1
1
1
1
1
1
1
Origine
Souris
6
5
Source
CHO Cells
6
2
1
1
1
Type de proteíne
Recombinant
Purification/Conjugué
Cette NOTCH2 protéine est marqué à la Fc Tag.
Application
SDS-PAGE (SDS)
Options
Specificité Binds to mouse DLL1 and DLL4.
 Réactivité croisée Souris
Attributs du produit The extracellular domain of mouse Notch2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1.
Pureté >95 % (SDS-PAGE)
niveau d'endotoxine <0.01EU/μg purified protein (LAL test, Lonza).
Nom de la protéine
Sujet Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
Poids moléculaire ~87kDa (SDS-PAGE)
UniProt O35516
Pathways Signalisation Notch, Stem Cell Maintenance
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 50 μL sterile water.
Concentration 1 mg/mL
Buffer Lyophilized. Contains PBS.
Stock 4 °C,-20 °C
Stockage commentaire Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.
Date de péremption 6 months
Produit citée dans: Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: "Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 11, pp. 7212-22, 2009 (PubMed).

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