C8G Protein (AA 21-202) (His tag)

N° du produit ABIN2115448

Détail du produit

Antigène: C8G (Complement Component 8, gamma Polypeptide (C8G))

Type de proteíne: Recombinant

Attributs du protein: AA 21-202

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette C8G protéine est marqué à la His tag.

Fonction: Recombinant Human Complement Component C8 γ Chain/C8G (N-6His)

Séquence: MGSSHHHHHH SSGLVPRGSH MQKPQRPRRP ASPISTIQPK ANFDAQQFAG TWLLVAVGSA CRFLQEQGHR AEATTLHVAP QGTAMAVSTF RKLDGICWQV RQLYGDTGVL GRFLLQARGA RGAVNVVVAE TDYQSFAVLY LERAGQLSVK LYARSLPVSD SVLSGFEQRV QEAHLTEDQI FYFPKYGFCE AADQFHVLDE VRR

Attributs du produit: Recombinant Human C8G is produced with our E. coli expression system. The target protein is expressed with sequence (Gln21-Arg202) of Human C8G fused with a polyhistidine tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: -80 °C

Stockage commentaire: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: C8G (Complement Component 8, gamma Polypeptide (C8G))

Autre désignation: Complement Component C8 gamma Chain (C8G Produits)

Synonymes: C8C Protein, complement C8 gamma chain Protein, complement component 8, gamma polypeptide Protein, C8G Protein, C8g Protein

Sujet: Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Patients lacking C8 are susceptible to certain bacterial infections.
Synonyms: Complement component C8 gamma chain,C8G

Poids moléculaire: 22.6kDa

UniProt: P07360

Pathways: Système du Complément