Cette Neuropilin 1 protéine est marqué à la Fc Tag.
Séquence
AA 22-644
Attributs du produit
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 96.5 kDa. The protein migrates as 120-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NRP1
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
> 95 %
SDS, WB, Imm, PC
Restrictions
For Research Use only
Format
Lyophilized
Buffer
Tris with Glycine, Arginine and NaCl, pH 7.5
Conseil sur la manipulation
Please avoid repeated freeze-thaw cycles.
Stock
-20 °C
Stockage commentaire
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Kerros, Tripathi, Zha, Mehrens, Sergeeva, Philips, Qiao, Peters, Katayama, Sukhumalchandra, Ruisaard, Perakis, St John, Lu, Mittendorf, Clise-Dwyer, Herrmann, Alatrash, Toniatti, Hanash, Ma, Molldrem: "Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells." dans: The Journal of biological chemistry, Vol. 292, Issue 24, pp. 10295-10305, (2017) (PubMed).
Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.