LIFR Protein (AA 45-833) (Fc Tag)
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- Antigène Voir toutes LIFR Protéines
- LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 45-833
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette LIFR protéine est marqué à la Fc Tag.
- Séquence
- AA 45-833
- Attributs du produit
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 115.5 kDa. The protein migrates as 135-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product LIFR Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
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- Antigène
- LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))
- Autre désignation
- LIF R (LIFR Produits)
- Synonymes
- A230075M04Rik Protein, AW061234 Protein, LIF Protein, CD118 Protein, LIF-R Protein, SJS2 Protein, STWS Protein, SWS Protein, leukemia inhibitory factor receptor Protein, LIF receptor alpha Protein, leukemia inhibitory factor receptor alpha Protein, Lifr Protein, LOC397451 Protein, LIFR Protein
- Sujet
- Leukemia inhibitory factor receptor is also known as LIFR, CD118, FLJ98106, FLJ99923, LIF-R, SJS2, STWS, SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.
- Poids moléculaire
- 115.5 kDa
- NCBI Accession
- NP_001121143
- Pathways
- Signalistation JAK/STAT, Growth Factor Binding
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