IRAK1 Protein (AA 618-712) (His tag)

N° du produit ABIN2468732

Détail du produit

Antigène: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Type de proteíne: Recombinant

Attributs du protein: AA 618-712

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette IRAK1 protéine est marqué à la His tag.

Application: Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)

Pureté: ~95 %

Information d'application

Indications d'application: This recombinant protein can be used for WB, ELISA, MS and neutralization assays.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 mM sodium phosphate, 500 mM NaCl, 25 mM imidazole, 10 % gycerol

Conseil sur la manipulation: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Stock: -80 °C

Stockage commentaire: Store in working aliquots at -70 °C.

Détail du antigène

Antigène: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Autre désignation: IRAK (IRAK1 Produits)

Synonymes: IRAK1 Protein, IRAK Protein, pelle Protein, AA408924 Protein, IRAK-1 Protein, IRAK1-S Protein, Il1rak Protein, Plpk Protein, mPLK Protein, RGD1563841 Protein, interleukin 1 receptor associated kinase 1 Protein, interleukin-1 receptor-associated kinase 1 Protein, IRAK1 Protein, irak1 Protein, Irak1 Protein

Sujet: Nuclear factor kappa B (NF-?B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-?B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF? and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently (1,2). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response (3). IRAK mediates a signaling cascade leading to NF-?B activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1,4).

Poids moléculaire: 15 kDa (Calculated)

ID gène: 3654

OMIM: 8928535

UniProt: P51617

Pathways: Signalisation NF-kappaB, Signalisation TLR, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades