PPARA Protein (His tag)

N° du produit ABIN2669420

Détail du produit

Antigène: PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PPARA protéine est marqué à la His tag.

Application: Protein Interaction (PI)

Attributs du produit: Recombinant PPARα is isolated from an E. coli strain that carries the coding sequence of the human PPARα under the control of a T7 promoter (accession number NM 005036). The purified recombinant protein has an amino terminal polyhistidine tag and is greater than 95 % homogeneous and contains no detectable protease, DNase and RNase activity.

Pureté: The purified recombinant protein has an amino terminal polyhistidine tag and is greater than 95 % homogeneous and contains no detectable protease, DNase and RNase activity.

Information d'application

Indications d'application: Recombinant PPARα is suitable for DNA and protein-protein interaction assays. 20 ng is sufficient for gelshift assays and 100 ng is sufficient for protein-protein interaction studies. The molecular weight of the protein is ~52 kDa. NOTE: The presence of Poly [d(I-C)] in buffers may affect protein functionality and should be avoided.

Restrictions: For Research Use only

Stockage

Concentration: 0.4 μg/μL

Détail du antigène

Antigène: PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))

Autre désignation: PPARalpha (PPARA Produits)

Synonymes: NR1C1 Protein, PPAR Protein, PPARalpha Protein, hPPAR Protein, LOC100136415 Protein, PPARALPHA Protein, nr1c1 Protein, xPPARalpha Protein, xppara Protein, 4933429D07Rik Protein, AW742785 Protein, Nr1c1 Protein, PPAR-alpha Protein, Ppar Protein, peroxisome proliferator activated receptor alpha Protein, peroxisome proliferator-activated receptor alpha Protein, peroxisome proliferator activated receptor alpha L homeolog Protein, PPARA Protein, LOC100136415 Protein, ppara.L Protein, Ppara Protein, ppara Protein

Sujet: Peroxisome Proliferator-Activated Receptors (PPARs) are nuclear receptors involved in lipid transport and metabolism. As such, their roles in chronic diseases such as diabetes, obesity, atherosclerosis and cancer are heavily investigated. Transcriptional activity of PPARs is regulated by fatty acid binding. Three PPAR isotypes have been identified: α, δ and Y. PPARγ stimulates lipolysis of circulating triglycerides and the subsequent uptake of fatty acids into adipose cells. PPARs bind to peroxisome proliferator response elements (PPREs) as heterodimers with the retinoid X receptor (RXR).

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Hepatitis C