Axin Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

N° du produit ABIN2715088

Détail du produit

Antigène: Axin (AXIN1) (Axin 1 (AXIN1))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 2

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Axin protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human Axin-1 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Référence

Cha, Cho, Lee, Lee, Jeong, Moon, Yun, Yang, Choi, Yoon, Kim, Kim, Kaduwal, Lee, Min, Kim, Han, Choi: "Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation." dans: Nature chemical biology, Vol. 12, Issue 8, pp. 593-600, (2016) (PubMed).

Détail du antigène

Antigène: Axin (AXIN1) (Axin 1 (AXIN1))

Autre désignation: Axin-1 (AXIN1 Produits)

Synonymes: AXIN1 Protein, axin Protein, fused Protein, xAxin Protein, LOC100226467 Protein, AXIN Protein, PPP1R49 Protein, AI316800 Protein, Axin Protein, Fu Protein, Kb Protein, Ki Protein, kinky Protein, knobbly Protein, AXIN1-RGS Protein, wu:fi22e03 Protein, wu:fj14c08 Protein, wu:fk11b03 Protein, zgc:109872 Protein, axin 1 Protein, axin 1 S homeolog Protein, axin 1 L homeolog Protein, AXIN1 Protein, axin1.S Protein, axin1.L Protein, Axin1 Protein, axin1 Protein

Sujet: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 91.5 kDa

NCBI Accession: NP_851393

Pathways: Signalisation WNT, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling