TNFSF4
(Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))
Type de proteíne
Recombinant
Activité biologique
Active
Attributs du protein
AA 51-183
Origine
Humain
Source
HEK-293 Cells
Purification/Conjugué
Cette TNFSF4 protéine est marqué à la His tag.
Séquence
AA 51-183
Attributs du produit
This protein carries a polyhistidine tag at the N-terminus, and has a calculated MW of 16.9 kDa. The predicted N-terminus is His. The reducing (R) protein migrates as 25-30 kDa in SDS-PAGE due to glycosylation.
TNFSF4
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
FACS
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46 % amino acid sequence identity with its mouse counterpart.