ADAM17 Protein (AA 18-563) (His tag)
Aperçu rapide pour ADAM17 Protein (AA 18-563) (His tag) (ABIN2870711)
Antigène
Voir toutes ADAM17 ProtéinesType de proteíne
Origine
Source
Pureté
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Attributs du protein
- AA 18-563
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Purification/Conjugué
- Cette ADAM17 protéine est marqué à la His tag.
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Séquence
- AA 18-563
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Attributs du produit
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 63.4 kDa. The protein migrates as 19 kDa and 20 kDa(Propeptide),55-66 kDa (Mature-ADAM17) and 75-94 kDa(Pro-ADAM17) under reducing (R) condition (SDS-PAGE) due to glycosylation.
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niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
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ADAM Metallopeptidase Domain 17 (ADAM17) (AA 752-824) protein (His-IF2DI Tag)
ADAM17 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-314) protein (GST tag)ADAM17 Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AP, AA
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 581-642) protein (mFc Tag)ADAM17 Origine: Humain Hôte: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 581-642) protein (Fc Tag)ADAM17 Origine: Humain Hôte: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 50 mM MES, 150 mM NaCl, pH 6.5
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Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
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Autre désignation
- ADAM17
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Sujet
- Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.
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Poids moléculaire
- 63.4 kDa
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UniProt
- Q9Z0F8
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Pathways
- Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
Antigène
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