Glycoprotein / GP (Virus) (AA 67-297) protein (His tag)

N° du produit ABIN2870785

Détail du produit

Antigène: Glycoprotein / GP (Virus)

Type de proteíne: Recombinant

Attributs du protein: AA 67-297

Origine: Human Respiratory Syncytial Virus (hRSV)

Source: HEK-293 Cells

Purification/Conjugué: His tag

Séquence: AA 67-297

Attributs du produit: rh RSV-G is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 26.2 kDa. The predicted N-terminus is His 67. The reducing (R) protein migrates as 60-94 kDa in SDS-PAGE due to glycosylation.

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Référence

Griffiths, Bilawchuk, McDonough, Jamieson, Elawar, Cen, Duan, Lin, Song, Casanova, Ogg, Jensen, Thienpont, Kumar, Hobman, Proud, Moraes, Marchant: "IGF1R is an entry receptor for respiratory syncytial virus." dans: Nature, Vol. 583, Issue 7817, pp. 615-619, (2020) (PubMed).

Détail du antigène

Antigène: Glycoprotein / GP (Virus)

Classe de substances: Viral Protein

Sujet: Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. Human respiratory syncytial virus A (strain Long) major surface glycoprotein G (RSV-G), a member of the pneumoviruses glycoprotein G family, is also known as attachment glycoprotein G and membrane-bound glycoprotein (mG), which contains a linear heparin binding domain essential for virus attachment to the host. Concretely speaking, RSV-G can attache the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Furthermore, RSV-G can also interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, RSV-G lacks both neuraminidase and hemagglutinating activities.

Poids moléculaire: 27.0 kDa

UniProt: P20895