Caspase 3 Protein (CASP3) (AA 29-175, partial) (His tag)

N° du produit ABIN5712415

Détail du produit

Antigène: Caspase 3 (CASP3)

Type de proteíne: Recombinant

Attributs du protein: partial, AA 29-175

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Caspase 3 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: SGISLDNSYK MDYPEMGLCI IINNKNFHKS TGMTSRSGTD VDAANLRETF RNLKYEVRNK NDLTREEIVE LMRDVSKEDH SKRSSFVCVL LSHGEEGIIF GTNGPVDLKK ITNFFRGDRC RSLTGKPKLF IIQACRGTEL DCGIETD

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: Caspase 3 (CASP3)

Autre désignation: CASP3 (CASP3 Produits)

Synonymes: CPP32 Protein, CPP32B Protein, SCA-1 Protein, A830040C14Rik Protein, AC-3 Protein, Apopain Protein, CC3 Protein, Caspase-3 Protein, Lice Protein, Yama Protein, mldy Protein, xcpp32 Protein, casp3 Protein, zgc:100890 Protein, CASP-3 Protein, caspase-3 Protein, caspase 3 Protein, caspase 3 S homeolog Protein, caspase 3, apoptosis-related cysteine peptidase a Protein, caspase 3, apoptosis-related cysteine peptidase Protein, CASP3 Protein, Casp3 Protein, casp3.S Protein, casp3a Protein

Sujet: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory elent binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the mbrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Poids moléculaire: 20.7 kDa

UniProt: P42574

Pathways: Apoptose, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation