VEGFR2/CD309 Protein (AA 20-764) (His tag)

N° du produit ABIN6253722

Détail du produit

Antigène: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 20-764

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette VEGFR2/CD309 protéine est marqué à la His tag.

Séquence: AA 20-764

Attributs du produit: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 86.2 kDa. The protein migrates as 100-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Classe de qualité: HPLC verified

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.

Détail du antigène

Antigène: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Autre désignation: VEGF R2 (VEGFR2 Produits)

Synonymes: CD309 Protein, FLK1 Protein, VEGFR Protein, VEGFR2 Protein, 6130401C07 Protein, Flk-1 Protein, Flk1 Protein, Krd-1 Protein, Ly73 Protein, VEGFR-2 Protein, sVEGFR-2 Protein, Vegfr-2 Protein, FLK-1 Protein, flk-1 Protein, vegfr-2 Protein, KDR Protein, FLK/KDR Protein, flk1 Protein, flk1b Protein, kdrb Protein, si:busm1-205d10.1 Protein, si:ch211-254j6.1 Protein, si:ch211-278f21.4 Protein, wu:fc31a09 Protein, fk52c05 Protein, flk Protein, kdr Protein, kdra Protein, vegfr2 Protein, vegfr4 Protein, vegr2 Protein, wu:fk52c05 Protein, kinase insert domain receptor Protein, kinase insert domain protein receptor Protein, vascular endothelial growth factor receptor kdr-like Protein, kinase insert domain receptor (a type III receptor tyrosine kinase) Protein, kinase insert domain receptor like Protein, KDR Protein, Kdr Protein, LOC100136647 Protein, kdr Protein, kdrl Protein

Sujet: Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Poids moléculaire: 85.2 kDa

Pathways: Signalisation RTK, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling