AHCY, also known as adenosylhomocysteinase, is an enzyme that catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). It regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Recombinant human AHCY protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: SAHH, Adenosylhomocysteinase, 2 S adenosyl L homocysteine, Adenosyl homo cys, Adenosylhomocysteinase, Adenosyl homocysteine, AdoHcy, S adenosyl homocysteine, S adenosyl L homocysteine hydrolase, SAH,. NCBI no.: NP_000678