TIGAR Protein (AA 1-270) (His tag)

N° du produit ABIN7279263

Détail du produit

Antigène: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Type de proteíne: Recombinant

Attributs du protein: AA 1-270

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette TIGAR protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: TIGAR, 1-270aa, Human, His tag, E.coli

Pureté: > 90 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 2mM DTT, 10% glycerol

Stock: 4 °C

Détail du antigène

Antigène: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Autre désignation: TIGAR (TIGAR Produits)

Synonymes: AA793651 Protein, AI595337 Protein, C79710 Protein, C85509 Protein, Tigar Protein, Trp53 induced glycolysis repulatory phosphatase Protein, Tigar Protein

Sujet: TIGAR, also known as TP53-induced glycolysis and apoptosis regulator, is a 270 amino acid protein induced by the p53 tumor suppressor pathway that functions to protect against oxidative stress. TIGAR specifically functions to block glycolysis, leading the pathway to the pentose phosphate shunt and decreasing the intracellular concentration of reactive oxygen species. These facts indicate that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses. Recombinant human TIGAR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: TP53-induced glycolysis and apoptosis regulator,. NCBI no.: NP_065108

Poids moléculaire: 32.6 kDa (294aa), confirmed by MALDI-TOF

Pathways: L'effet Warburg