TICAM2 Protein (AA 1-235) (His tag)

N° du produit ABIN667668

Détail du produit

Antigène: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Type de proteíne: Recombinant

Attributs du protein: AA 1-235

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette TICAM2 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: TICAM2, 1-235aa, Human, His tag, E.coli

Pureté: > 85 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl

Stock: 4 °C

Détail du antigène

Antigène: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Autre désignation: TICAM2 (TICAM2 Produits)

Synonymes: MyD88-4 Protein, TICAM-2 Protein, TIRAP3 Protein, TIRP Protein, TRAM Protein, B430113A10 Protein, Tirp Protein, Trif Protein, toll like receptor adaptor molecule 2 Protein, toll-like receptor adaptor molecule 2 Protein, TICAM2 Protein, Ticam2 Protein

Sujet: Toll TIR domain-containing adapter molecule 2, also known as TICAM2, is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TICAM-2, a cytoplasmic protein, physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TLR4 signaling to TICAM-1, which in turn activates IRF-3. It is involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Recombinant human TICAM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: TIR domain-containing adapter molecule 2, TICAM-2, TIRAP3, TIRP, TRAM. NCBI no.: NP_067681

Poids moléculaire: 29.4 kDa (259aa) confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades