Leptin Protein (LEP)
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- Antigène Voir toutes Leptin (LEP) Protéines
- Leptin (LEP)
- Type de proteíne
- Recombinant
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Origine
- Souris
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Attributs du produit
- Leptin Mouse, Recombinant, E.coli
- Pureté
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product LEP Protéine
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In Phosphate buffered saline pH7.4
- Stock
- 4 °C
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- Antigène
- Leptin (LEP)
- Autre désignation
- Leptin (LEP Produits)
- Synonymes
- ob Protein, obese Protein, LEPD Protein, OB Protein, OBS Protein, leptin Protein, Lep Protein, LEP Protein, lep Protein
- Sujet
- Leptin is a 16-kDa nonglycosylated hormone that is produced in mature adipocytes. Leptin acts primarily in the hypothalamus to reduce food intake and body weight. In ob/ob mice, the gene encoding leptin is mutated, resulting in morbid obesity and associated abnormalities, including hyperphagia, hypothermia, diabetes and infertility. Originally discovered in the mouse, the cDNA for leptin has been so far cloned from a variety of species including human, rat, cow, chicken, pig, sheep and dog. Recombinant mouse leptin was overexpressed as insoluble protein aggregate in E.coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. Synonyms: LEP, OB, OBS, Leptin Mouse, Obesity factor, Obese protein, Leptin,. NCBI no.: NP_032519
- Poids moléculaire
- 16 kDa (147 aa), confirmed by MALDI-TOF.
- Pathways
- Signalistation JAK/STAT, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
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