ALK Protein (Fc Tag)

N° du produit ABIN7272289

Détail du produit

Antigène: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette ALK protéine est marqué à la Fc Tag.

Fonction: Recombinant Human ALK Protein with C-terminal human Fc tag

Specificité: ALK (Ser31-Gln692) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Purification: affinity purification

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Autre désignation: ALK (ALK Produits)

Synonymes: Tcrz Protein, CD246 Protein, NBLST3 Protein, ALK Protein, anaplastic lymphoma kinase Protein, anaplastic lymphoma receptor tyrosine kinase Protein, ALK receptor tyrosine kinase Protein, Alk Protein, ALK Protein

Sujet: Synonymes: CD246, NBLST3
Description: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

Poids moléculaire: predicted molecular mass of 136.4 kDa after removal of the signal peptide.The apparent molecular mass of ALK-hFc is 130-250 kDa due to glycosylation.

UniProt: Q9UM73

Pathways: Signalisation RTK