CD247 Protein (GST tag)

N° du produit ABIN7317295

Détail du produit

Antigène: CD247 (CD247 Molecule (CD247))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CD247 protéine est marqué à la GST tag.

Fonction: Recombinant Human CD247/CD3-ZETA Protein (GST Tag)

Séquence: Arg52-Arg164

Attributs du produit: A DNA sequence encoding the mature form of human CD247 (P20963-1) (Arg52-Arg164) was fused with the GST tag at the N-terminus.

Pureté: > 92 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD247 (CD247 Molecule (CD247))

Autre désignation: CD247/CD3-ZETA (CD247 Produits)

Synonymes: CD3-ZETA Protein, CD3H Protein, CD3Q Protein, CD3Z Protein, T3Z Protein, TCRZ Protein, 4930549J05Rik Protein, A430104F18Rik Protein, AW552088 Protein, Cd3 Protein, Cd3-eta Protein, Cd3-zeta Protein, Cd3h Protein, Cd3z Protein, Cd3zeta Protein, T3z Protein, Tcrk Protein, Tcrz Protein, LOC100136514 Protein, LOC100136549 Protein, LOC100305023 Protein, CD247 Protein, TCRzeta Protein, CD247 molecule Protein, CD247 antigen Protein, CD3zeta-2 Protein, CD3zeta-1 Protein, Cd247 molecule Protein, CD247 Protein, Cd247 Protein, cd3z Protein, cd247 Protein

Sujet:

Background: CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

Synonym: CD3-ZETA;CD3H;CD3Q;CD3Z;IMD25;T3Z;TCRZ

Poids moléculaire: 40.2 kDa

Pathways: TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway