FGFR1 Protein (Fc Tag)

N° du produit ABIN7320382

Détail du produit

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette FGFR1 protéine est marqué à la Fc Tag.

Fonction: Recombinant Mouse FGFR1/CD331 Protein (Fc Tag)(Active)

Séquence: Met 1-Glu 376

Attributs du produit: A DNA sequence encoding the extracellular domain (Met 1-Glu 376) of mouse FGFR1 isoform 1 (P16092-1) was as fused with the Fc region of human IgG1 at the C-terminus.

Pureté: > 97 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to inhibit mouse FGF acidic (aFGF/FGF1) dependent proliferation of Balb/C 3T3 mouse fibroblasts. The ED50 for this effect is typically 6-25 ng/mL in the presence of 0.5 ng/mL of mouse FGF acidic (aFGF/FGF1).

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Autre désignation: FGFR1/CD331 (FGFR1 Produits)

Synonymes: FGFR Protein, fgfr Protein, X1FGFR Protein, XFGFR-1 Protein, XFGFRA2 Protein, bfgfr Protein, cek Protein, fgfr1 Protein, flg Protein, flt-2 Protein, flt2 Protein, kal2 Protein, ogd Protein, xfgfr1 Protein, CG7223 Protein, CT22273 Protein, CT39172 Protein, DFGF-R1 Protein, DFGF-R2 Protein, DFR-1 Protein, DFR1 Protein, DFR1/DFGF-R2 Protein, DPR3 Protein, DTRK(FR1) Protein, Dfr-1 Protein, Dfr1 Protein, DmHD-38 Protein, Dmel\\CG7223 Protein, Dtk1 Protein, EMS2 Protein, FGF-R2 Protein, FGFR2 Protein, FR1 Protein, Fr1 Protein, HD-38 Protein, HTL/FGFR1 Protein, Htl Protein, Tk1 Protein, dtk1 Protein, i100 Protein, i150 Protein, i79 Protein, j372 Protein, cd331 Protein, fgfbr Protein, fgfr-1 Protein, hbgfr Protein, n-sam Protein, ach Protein, cd333 Protein, cek2 Protein, fgfr-3 Protein, hsfgfr3ex Protein, jtk4 Protein, BFGFR Protein, CD331 Protein, CEK Protein, FGFBR Protein, FGFR-1 Protein, FLG Protein, FLT-2 Protein, FLT2 Protein, HBGFR Protein, HH2 Protein, KAL2 Protein, N-SAM Protein, OGD Protein, bFGF-R-1 Protein, AW208770 Protein, Eask Protein, Fgfr-1 Protein, Flt-2 Protein, Hspy Protein, FLG-1 Protein, FGFRI Protein, x1fgfr Protein, cb231 Protein, sb:cb231 Protein, fibroblast growth factor receptor Protein, fibroblast growth factor receptor 1 S homeolog Protein, basic fibroblast growth factor receptor 1 Protein, heartless Protein, fibroblast growth factor receptor 1 Protein, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) L homeolog Protein, Fibroblast growth factor receptor 1 Protein, fibroblast growth factor receptor 1 L homeolog Protein, fibroblast growth factor receptor 1a Protein, FGFR Protein, fgfr Protein, fgfr1.S Protein, CpipJ_CPIJ005849 Protein, htl Protein, fgfr1 Protein, fgfr3.L Protein, FGFR1 Protein, Fgfr1 Protein, fgfr1.L Protein, fgfr1a Protein

Sujet:

Background: FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ,idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: AW208770;bFGF-R-1;c-fgr;Eask;Fgfr-1;FLG;Flt-2;Hspy;MFR

Poids moléculaire: 66.5 kDa

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins