GFPT1 Protéine

N° du produit ABIN7317673

Détail du produit

Antigène: GFPT1 (Glutamine--Fructose-6-Phosphate Transaminase 1 (GFPT1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Fonction: Recombinant Human GFPT1/GFAT Protein

Séquence: Gln 332-Glu 699

Attributs du produit: The sequence corresponding to amino acids (Gln 332-Glu 699) of human GFAT (AAA58502.1) was expressed and purified with two amino acids (Gly & Pro) at the N-terminus.

Pureté: > 97 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: GFPT1 (Glutamine--Fructose-6-Phosphate Transaminase 1 (GFPT1))

Autre désignation: GFPT1/GFAT (GFPT1 Produits)

Synonymes: gfat Protein, 2810423A18Rik Protein, AI324119 Protein, AI449986 Protein, GFA Protein, GFAT Protein, GFAT1 Protein, GFAT1m Protein, Gfpt Protein, CMSTA1 Protein, GFAT 1 Protein, GFPT Protein, GFPT1L Protein, MSLG Protein, glutamine--fructose-6-phosphate transaminase 1 Protein, glutamine--fructose-6-phosphate transaminase 1 S homeolog Protein, glutamine fructose-6-phosphate transaminase 1 Protein, GFPT1 Protein, gfpt1.S Protein, Gfpt1 Protein

Sujet:

Background: Glutamine:fructose-6-phosphate amidotransferase 1 (GFAT), also known as GFPT1, is a member of the N-terminal nucleophile aminotransferases and the first rate-limiting enzyme for the entry of glucose into the hexosamine biosynthesis pathway (HBP) in mammals. GFAT transfers the amino group from the L-glutamine amide to the D-fructose 6-phosphate, producing glutamic acid and glucosamine 6-phosphate. GFAT exists as a homotetramer in cytoplasm, and is proposed to be most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. The full length of human GFAT contains 1 glutamine amidotransferase type-2 domain which catalyzes amide nitrogen transfer from glutamine to the appropriate substrate, and 2 SIS (Sugar Isomerase) domains found in many phosphosugar isomerases and phosphosugar binding proteins.Two isoforms of gfat have been identified: GFAT1 is predominantly expressed in skeletal muscle, whereas GFAT2 is expressed mainly in the central nervous system.

Synonym: CMSTA1,GFA,GFAT,GFAT1,GFAT1m,GFPT,GFPT1L,MSLG

Poids moléculaire: 41.5 kDa

Pathways: ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process