NTRK3 Protein (His tag)

N° du produit ABIN7320316

Détail du produit

Antigène: NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette NTRK3 protéine est marqué à la His tag.

Fonction: Recombinant Mouse TrkC/NTRK3 Protein (His Tag)(Active)

Séquence: Met 1-Thr 429

Attributs du produit: A DNA sequence encoding the extracellular domain of mouse TrkC (NP_032772.3) (Met 1-Thr 429) was expressed, with a C-terminal polyhistidine tag.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Immobilized mouse NTRK3-His at 10 μg/ml (100 μl/well) can bind biotinylated human NT3, The EC50 of biotinylated human NT3 is 0.04-0.08 μg/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))

Autre désignation: TrkC/NTRK3 (NTRK3 Produits)

Synonymes: TRKC Protein, gp145(trkC) Protein, trkC Protein, AW125844 Protein, Ntrk3_tv3 Protein, TrkC Protein, neurotrophic receptor tyrosine kinase 3 Protein, neurotrophic tyrosine kinase, receptor, type 3 Protein, NTRK3 Protein, Ntrk3 Protein

Sujet:

Background: NT-3 growth factor receptor also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC/NTRK3 is widely expressed in the developing and adult nervous system. In later embryonic development, TrkC/NTRK3 is expressed in various structures of the CNS including the caudatoputamen, septal nuclei, cerebellum, and brainstem. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. In the PNS, trkC hybridization appears to correlate, both temporally and spatially, with the outgrowth of axons toward their peripheral targets. TrkC/NTRK3 is widely expressed in the three identified branches of the mammalian nervous system and appears to correlate with the expression of NT-3, its cognate ligand. The apparent colocalization of trkC transcripts with NT-3 raises the possibility this neurotrophin exerts its trophic effects by a paracrine and/or autocrine mechanism. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: GP145-TrkB/GP95-TrkB;Tkrb;trk-B;trkB

Poids moléculaire: 46.1 kDa

NCBI Accession: NP_032772

Pathways: Signalisation RTK, Neurotrophin Signaling Pathway, Regulation of Cell Size