PDE1B Protein (GST tag,His tag)

N° du produit ABIN7317495

Détail du produit

Antigène: PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette PDE1B protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Human PDE1B Protein (His & GST Tag)

Séquence: Met 1-Asp 536

Attributs du produit: A DNA sequence encoding the human PDE1B long isoform (Q01064-1) (Met 1-Asp 536) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 94 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))

Autre désignation: PDE1B (PDE1B Produits)

Synonymes: 63kDa Protein, Pde1b1 Protein, PDE1B1 Protein, PDES1B Protein, Aop2 Protein, phosphodiesterase 1B, Ca2+-calmodulin dependent Protein, phosphodiesterase 1B Protein, Pde1b Protein, PDE1B Protein

Sujet:

Background: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein which belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Phosphodiesterase-10A (PDE10A), Phosphodiesterase-1B (PDE1B), Phosphodiesterase-4B (PDE4B), and Phosphodiesterase-4A (PDE4A) are important regulators of signal transduction in striatum due to their catalysis of cyclic AMP and cyclic GMP. PDE1B is highly expressed in the striatum. It binds two divalent metal cations per subunit. Site one of PDE1B may preferentially bind zinc ions, while site two of PDE1B has a preference for magnesium and/or manganese ions. PDE1B is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. It has a preference for cGMP as a substrate.

Synonym: PDE1B1;PDES1B

Poids moléculaire: 89.2 kDa

Pathways: Neurotrophin Signaling Pathway, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma