PDGFB Protein (His tag)

N° du produit ABIN7321293

Détail du produit

Antigène: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Type de proteíne: Recombinant

Origine: Rat

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PDGFB protéine est marqué à la His tag.

Fonction: Recombinant Rat PDGF-B Protein (His Tag)

Séquence: Ser74-Thr182

Attributs du produit: A DNA sequence encoding the Rat PDGF-B (Q05028-1) (Ser74-Thr182) was expressed with a polyhistidine tag at the N-terminus.

Pureté: >85 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris,1 mM EDTA,25 % glycerol, pH 8.0

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Autre désignation: PDGF-B (PDGFB Produits)

Synonymes: PDGF-2 Protein, PDGF2 Protein, SIS Protein, SSV Protein, c-sis Protein, pdgf2 Protein, sis Protein, si:ch211-79m20.1 Protein, si:dkey-261d11.1 Protein, PDGF-B Protein, Sis Protein, platelet derived growth factor subunit B Protein, platelet-derived growth factor beta polypeptide Protein, platelet derived growth factor subunit B S homeolog Protein, platelet-derived growth factor beta polypeptide a Protein, platelet derived growth factor, B polypeptide Protein, PDGFB Protein, pdgfb.S Protein, pdgfba Protein, Pdgfb Protein

Sujet:

Background: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Synonym: Becaplermin,PDGF 2,PDGF B chain,PDGF subunit B,PDGF-2,PDGF2,Pdgfb,PDGFB,Platelet derived growth factor 2,Platelet-derived growth factor B chain,Platelet-derived growth factor beta polypeptide,Platelet-derived growth factor subunit B,Proto-oncogene c-Sis,SIS,SSV

Poids moléculaire: 12.2 kDa

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling